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Semicarbazone derivatives as urease inhibitors: Synthesis, biological evaluation, molecular docking studies and in-silico ADME evaluation.

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第一作者： Syeda Uroos,Qazi

第一单位： H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Pakistan.

作者： Syeda Uroos,Qazi ^[1] ; Shafiq Ur,Rahman ^[2] ; Asia Naz,Awan ^[3] ; Mariya,Al-Rashida ^[4] ; Rima D,Alharthy ^[5] ; Asnuzilawati,Asari ^[6] ; Abdul,Hameed ^[7] ; Jamshed,Iqbal ^[8]

作者单位： H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Pakistan. ^[1] COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan. ^[2] Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Pakistan. ^[3] Department of Chemistry, Forman Christian College (A Chartered University), Ferozepur Road, Lahore 54600, Pakistan. ^[4] Department of Chemistry, Science and Arts College, Rabigh Campus, King Abdulaziz University, Jeddah, Saudi Arabia. ^[5] School of Fundamental Science, Universiti Malaysia Terengganu, 21030 kuala Terengganu, Terengganu, Malaysia. ^[6] H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan. Electronic address: abdul.hameed@iccs.edu. ^[7] COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan. Electronic address: drjamshed@ciit.net.pk. ^[8]

关键词 ADME evaluation Molecular docking Semicarbazide Semicarbazones Urease inhibition

医学主题词刀豆属(Canavalia);催化域(Catalytic Domain);酶抑制剂(Enzyme Inhibitors);分子结构(Molecular Structure);缩氨基脲类(Semicarbazones);构效关系(Structure-Activity Relationship);尿素酶(Urease)

DOI 10.1016/j.bioorg.2018.03.029

PMID 29709568

发布时间 2019-02-21

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