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Synthesis of a Novel Series of Amino Acid Prodrugs Based on Thienopyridine Scaffolds and Evaluation of Their Antiplatelet Activity.

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第一作者： Nan,Lu

第一单位： School of Pharmaceutical Engineering, and Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education), Shenyang Pharmaceutical University, Shenyang 110016, China. lunantj@126.com.;Tianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China. lunantj@126.com.

作者： Nan,Lu ^[1] ; Lingjun,Li ^[2] ; Xuemin,Zheng ^[3] ; Shijun,Zhang ^[4] ; Yuquan,Li ^[5] ; Jing,Yuan ^[6] ; Qunchao,Wei ^[7] ; Youjun,Xu ^[8] ; Fancui,Meng ^[9]

作者单位： School of Pharmaceutical Engineering, and Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education), Shenyang Pharmaceutical University, Shenyang 110016, China. lunantj@126.com.;Tianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China. lunantj@126.com. ^[1] Tianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China. lilj@tjipr.com. ^[2] Tianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China. zhengxm@tjipr.com. ^[3] Tianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China. zhangsj@tjipr.com. ^[4] Tianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China. liyq@tjipr.com. ^[5] Tianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China. yuanj@tjipr.com. ^[6] Tianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China. weiqc@tjipr.com. ^[7] School of Pharmaceutical Engineering, and Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education), Shenyang Pharmaceutical University, Shenyang 110016, China. xuyoujun@syphu.edu.cn. ^[8] Tianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China. mengfc@tjipr.com. ^[9]

关键词 ADP-induced platelet aggregation P2Y12 receptor antagonist amino acid prodrugs antiplatelet thienopyridines