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Effects of selexipag and its active metabolite in contrasting the profibrotic myofibroblast activity in cultured scleroderma skin fibroblasts.

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第一作者： Maurizio,Cutolo

第一单位： Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Polyclinic San Martino Hospital, Genoa, Italy. mcutolo@unige.it.

作者： Maurizio,Cutolo ^[1] ; Barbara,Ruaro ^[2] ; Paola,Montagna ^[2] ; Renata,Brizzolara ^[2] ; Emanuela,Stratta ^[3] ; Amelia Chiara,Trombetta ^[2] ; Stefano,Scabini ^[3] ; Pier Paolo,Tavilla ^[4] ; Aurora,Parodi ^[4] ; Claudio,Corallo ^[5] ; Nicola,Giordano ^[5] ; Sabrina,Paolino ^[2] ; Carmen,Pizzorni ^[2] ; Alberto,Sulli ^[2] ; Vanessa,Smith ^[6] ; Stefano,Soldano ^[2]

作者单位： Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Polyclinic San Martino Hospital, Genoa, Italy. mcutolo@unige.it. ^[1] Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Polyclinic San Martino Hospital, Genoa, Italy. ^[2] Oncologic Surgery, Department of Surgery, Polyclinic San Martino Hospital, Genoa, Italy. ^[3] Department of Health Science, Unit of Dermatology, University of Genova, Polyclinic San Martino Hospital, Genoa, Italy. ^[4] Department of Medicine, Surgery and Neurosciences, Scleroderma Unit, University of Siena, Siena, Italy. ^[5] Department of Rheumatology, Ghent University Hospital, Ghent, Belgium. ^[6]

关键词 Connective tissue diseases Fibrosis Prostacyclin receptor agonists Skin fibroblasts Systemic sclerosis