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Predicting Human Clearance of Organic Anion Transporting Polypeptide Substrates Using Cynomolgus Monkey: In Vitro-In Vivo Scaling of Hepatic Uptake Clearance.

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第一作者： Tom,De Bruyn

第一单位： Centre for Applied Pharmacokinetic Research, Division of Pharmacy and Optometry, School of Medicine, Biology and Health Sciences, University of Manchester, Manchester, United Kingdom (T.D.B., A.U., C.C., A.G., J.B.H.) and Pharmacokinetics, Dynamics and Drug Metabolism (R.E.K., Y.B., M.N., A.D.R., L.M.T., M.V.S.V) and Research Formulations, Pharmaceutical Sciences, (S.M.) Medicines Design, Pfizer, Inc., Groton, Connecticut.

作者： Tom,De Bruyn ^[1] ; Ayşe,Ufuk ^[1] ; Carina,Cantrill ^[1] ; Rachel E,Kosa ^[1] ; Yi-An,Bi ^[1] ; Mark,Niosi ^[1] ; Sweta,Modi ^[1] ; A David,Rodrigues ^[1] ; Larry M,Tremaine ^[1] ; Manthena V S,Varma ^[1] ; Aleksandra,Galetin ^[1] ; J Brian,Houston ^[2]

作者单位： Centre for Applied Pharmacokinetic Research, Division of Pharmacy and Optometry, School of Medicine, Biology and Health Sciences, University of Manchester, Manchester, United Kingdom (T.D.B., A.U., C.C., A.G., J.B.H.) and Pharmacokinetics, Dynamics and Drug Metabolism (R.E.K., Y.B., M.N., A.D.R., L.M.T., M.V.S.V) and Research Formulations, Pharmaceutical Sciences, (S.M.) Medicines Design, Pfizer, Inc., Groton, Connecticut. ^[1] Centre for Applied Pharmacokinetic Research, Division of Pharmacy and Optometry, School of Medicine, Biology and Health Sciences, University of Manchester, Manchester, United Kingdom (T.D.B., A.U., C.C., A.G., J.B.H.) and Pharmacokinetics, Dynamics and Drug Metabolism (R.E.K., Y.B., M.N., A.D.R., L.M.T., M.V.S.V) and Research Formulations, Pharmaceutical Sciences, (S.M.) Medicines Design, Pfizer, Inc., Groton, Connecticut brian.houston@manchester.ac.uk. ^[2]