换一批
换一批Computational simulations assessment of mutations impact on streptokinase (SK) from a group G streptococci with enhanced activity - insights into the functional roles of structural dynamics flexibility of SK and stabilization of SK-μplasmin catalytic complex.
作者：
关键词
Cα: C-alphaHbonds: Hydrogen bondsK: kringleMD simulation: Molecular dynamics simulationPAs: Plasminogen activatorsPDB: Protein Data BankPg: PlasminogenPm: PlasminR: RegionRING: Residue interaction network generatorRINs: Residue interaction networksRMSD: Root mean square deviationRMSF: Root mean square fluctuationSK: StreptokinaseVDW: van der Waalsactivitymolecular dynamics simulationplasminogenresidue interaction networkstreptokinasetPAs: Tissue type-PAsμPm: microplasmin
主题词
氨基酸类(Amino Acids);生物催化(Biocatalysis);计算机模拟(Computer Simulation);纤维蛋白溶酶(Fibrinolysin);氢键合(Hydrogen Bonding);模型, 分子(Models, Molecular);突变(Mutation);蛋白质稳定性(Protein Stability);结果可重复性(Reproducibility of Results);链球菌属(Streptococcus);链激酶(Streptokinase)
DOI
10.1080/07391102.2018.1472668
PMID
29726798
发布时间
2020-06-17
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