Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment.

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作者： Wenwen,Liu ^[1] ; Huan,Wang ^[2] ; Xiaokang,Li ^[1] ; Yixiang,Xu ^[1] ; Jian,Zhang ^[3] ; Wei,Wang ^[3] ; Qi,Gong ^[3] ; Xiaoxia,Qiu ^[1] ; Jin,Zhu ^[1] ; Fei,Mao ^[4] ; Haiyan,Zhang ^[5] ; Jian,Li ^[6]

作者单位： Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Mei Long Road, Shanghai 200237, China. ^[1] CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China. ^[2] CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China. ^[3] Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Mei Long Road, Shanghai 200237, China. Electronic address: maofei@ecust.edu.cn. ^[4] CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 201203, China. Electronic address: hzhang@simm.ac.cn. ^[5] Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Mei Long Road, Shanghai 200237, China. Electronic address: jianli@ecust.edu.cn. ^[6]

关键词 5-HT reuptake inhibition 5-HT(1A) agonist ChE inhibition Cognitive impairment Depression Multitarget-directed ligand