首页> European journal of medicinal chemistry> Discovery of novel 2,4-diarylaminopyrimidine derivatives as potent and selective epidermal growth factor receptor (EGFR) inhibitors against L858R/T790M resistance mutation.

Discovery of novel 2,4-diarylaminopyrimidine derivatives as potent and selective epidermal growth factor receptor (EGFR) inhibitors against L858R/T790M resistance mutation.

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第一作者： Qi,Yan

第一单位： School of Pharmacy, Fudan University, Shanghai, 201203, China.

作者： Qi,Yan ^[1] ; Yuzhe,Chen ^[2] ; Baiyou,Tang ^[3] ; Qiang,Xiao ^[1] ; Rong,Qu ^[2] ; Linjiang,Tong ^[4] ; Jian,Liu ^[1] ; Jian,Ding ^[4] ; Yi,Chen ^[4] ; Ning,Ding ^[1] ; Wenfu,Tan ^[5] ; Hua,Xie ^[6] ; Yingxia,Li ^[7]

作者单位： School of Pharmacy, Fudan University, Shanghai, 201203, China. ^[1] Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China. ^[2] Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China; Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. ^[3] Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. ^[4] School of Pharmacy, Fudan University, Shanghai, 201203, China. Electronic address: wftan@fudan.edu.cn. ^[5] Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. Electronic address: hxie@simm.ac.cn. ^[6] School of Pharmacy, Fudan University, Shanghai, 201203, China. Electronic address: liyx417@fudan.edu.cn. ^[7]

关键词 AZD9291 EGFR inhibitors Mutant selective inhibitors Pyrimidine derivatives T790M