Filopodia Conduct Target Selection in Cortical Neurons Using Differences in Signal Kinetics of a Single Kinase.

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作者： Yu-Ting,Mao ^[1] ; Julia X,Zhu ^[1] ; Kenji,Hanamura ^[2] ; Giuliano,Iurilli ^[3] ; Sandeep Robert,Datta ^[3] ; Matthew B,Dalva ^[4]

作者单位： Department of Neuroscience and Jefferson Synaptic Biology Center, The Vickie and Jack Farber Institute, Jefferson Hospital for Neuroscience, Thomas Jefferson University, Suite 461, 900 Walnut Street, Philadelphia, PA 19107, USA. ^[1] Department of Neuroscience and Jefferson Synaptic Biology Center, The Vickie and Jack Farber Institute, Jefferson Hospital for Neuroscience, Thomas Jefferson University, Suite 461, 900 Walnut Street, Philadelphia, PA 19107, USA; Department of Neurobiology and Behavior, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi City, Gunma 371-8511, Japan. ^[2] Department of Neurobiology, Harvard Medical School, Room 336 Warren Alpert Building, 220 Longwood Avenue, Boston, MA 02115, USA. ^[3] Department of Neuroscience and Jefferson Synaptic Biology Center, The Vickie and Jack Farber Institute, Jefferson Hospital for Neuroscience, Thomas Jefferson University, Suite 461, 900 Walnut Street, Philadelphia, PA 19107, USA. Electronic address: matthew.dalva@jefferson.edu. ^[4]

关键词 cell signaling kinase reporter modeling neuronal development optogenetics photoactivation synaptogenesis technology development transfectable indicator