Functional Characterization of the Osteoarthritis Genetic Risk Residing at ALDH1A2 Identifies rs12915901 as a Key Target Variant.

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作者： Colin,Shepherd ^[1] ; Dongxing,Zhu ^[2] ; Andrew J,Skelton ^[1] ; Jennifer,Combe ^[1] ; Harrison,Threadgold ^[1] ; Linyi,Zhu ^[3] ; Tonia L,Vincent ^[3] ; Paul,Stuart ^[4] ; Louise N,Reynard ^[1] ; John,Loughlin ^[1]

作者单位： Newcastle University, Newcastle upon Tyne, UK. ^[1] Newcastle University, Newcastle upon Tyne, UK, and Guangzhou Institute of Cardiovascular Disease, The Second Affiliated Hospital, and Guangzhou Medical University, Guangzhou, China. ^[2] Arthritis Research UK Centre for OA Pathogenesis, University of Oxford, Oxford, UK. ^[3] Newcastle University Teaching Hospitals NHS Trust, Freeman Hospital, Newcastle upon Tyne, UK. ^[4]

主题词等位基因(Alleles);软骨, 关节(Cartilage, Articular);软骨细胞(Chondrocytes);女(雌)性(Female);基因表达(Gene Expression);疾病遗传易感性(Genetic Predisposition to Disease);手(Hand);人类(Humans);男(雄)性(Male);中年人(Middle Aged);骨关节炎(Osteoarthritis);多态性, 单核苷酸(Polymorphism, Single Nucleotide);视黄醛脱氢酶(Retinal Dehydrogenase);危险因素(Risk Factors);信号传导(Signal Transduction)

DOI 10.1002/art.40545

PMID 29732726

发布时间 2021-01-09

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Arthritis & rheumatology (Hoboken, N.J.)

2018年70卷10期

1577-1587页

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Functional Characterization of the Osteoarthritis Genetic Risk Residing at ALDH1A2 Identifies rs12915901 as a Key Target Variant.

Arthritis & rheumatology (Hoboken, N.J.)

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Arthritis & rheumatology (Hoboken, N.J.)

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Functional Characterization of the Osteoarthritis Genetic Risk Residing at ALDH1A2 Identifies rs12915901 as a Key Target Variant.

Arthritis & rheumatology (Hoboken, N.J.)

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Arthritis & rheumatology (Hoboken, N.J.)

相关期刊

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