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Pharmacokinetics and safety of fluconazole and micafungin in neonates with systemic candidiasis: a randomized, open-label clinical trial.

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第一作者： S,Leroux

第一单位： Department of Pediatric Pharmacology and Pharmacogenetics, Clinical Investigation Center 1426 Robert-Debré Paediatric Hospital, Assistance Publique Hôpitaux de Paris, Paris, France.

作者： S,Leroux ^[1] ; E,Jacqz-Aigrain ^[1] ; V,Elie ^[1] ; F,Legrand ^[2] ; C,Barin-Le Guellec ^[1] ; B,Aurich ^[3] ; V,Biran ^[4] ; B,Dusang ^[5] ; S,Goudjil ^[6] ; S,Coopman ^[7] ; R,Garcia Sanchez ^[1] ; W,Zhao ^[8] ; P,Manzoni ; FP7 TINN (Treat Infections in NeoNates) consortium

作者单位： Department of Pediatric Pharmacology and Pharmacogenetics, Clinical Investigation Center 1426 Robert-Debré Paediatric Hospital, Assistance Publique Hôpitaux de Paris, Paris, France. ^[1] EA4245, Faculté de Médecine, Université François Rabelais, Tours, France. ^[2] UMR 1141 INSERM, Université Paris 7-Diderot, Neonatal Intensive Care Unit, Robert-Debré Paediatric Hospital, Assistance Publique Hôpitaux de Paris, Paris, France. ^[3] Neonatal Intensive Care Unit, CHU de La Réunion, Saint Pierre, La Réunion, France. ^[4] Neonatal Care Unit, CHU Amiens, Amiens, France. ^[5] Centre d'Investigation Clinique, CIC1403, Lille University Hospital, Lille, France. ^[6] Hospital Universitario de Salamanca, Spain. ^[7] Neonatal Intensive Care Unit, S. Anna Hospital, Torino, Italy. ^[8]

关键词 Candida spp fluconazole micafungin neonate pharmacokinetics safety