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The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity.

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第一作者： Fabia,Filipello

第一单位： Humanitas University, Department of Biomedical Sciences, Via Rita Levi Montalcini, 20090 Pieve Emanuele - Milan, Italy.

作者： Fabia,Filipello ^[1] ; Raffaella,Morini ^[2] ; Irene,Corradini ^[3] ; Valerio,Zerbi ^[4] ; Alice,Canzi ^[1] ; Bernadeta,Michalski ^[5] ; Marco,Erreni ^[6] ; Marija,Markicevic ^[4] ; Chiara,Starvaggi-Cucuzza ^[2] ; Karel,Otero ^[7] ; Laura,Piccio ^[8] ; Francesca,Cignarella ^[8] ; Fabio,Perrucci ^[2] ; Matteo,Tamborini ^[2] ; Marco,Genua ^[6] ; Lawrence,Rajendran ^[9] ; Elisabetta,Menna ^[3] ; Stefania,Vetrano ^[1] ; Margaret,Fahnestock ^[5] ; Rosa Chiara,Paolicelli ^[9] ; Michela,Matteoli ^[10]

作者单位： Humanitas University, Department of Biomedical Sciences, Via Rita Levi Montalcini, 20090 Pieve Emanuele - Milan, Italy. ^[1] Laboratory of Pharmacology and Brain Pathology, Humanitas Clinical and Research Center, Via Manzoni 56, 20089 Rozzano - Milan, Italy. ^[2] Laboratory of Pharmacology and Brain Pathology, Humanitas Clinical and Research Center, Via Manzoni 56, 20089 Rozzano - Milan, Italy; IN-CNR, 20129 Milano, Italy. ^[3] Neural Control of Movement Lab, HEST, ETH Zürich, Winterthurerstrasse 190, 8057 Zurich, Switzerland. ^[4] Department of Psychiatry & Behavioural Neurosciences, HSC-4N80, McMaster University, Hamilton, ON, Canada. ^[5] Department of Immunology and Inflammation, Humanitas Clinical and Research Center, Via Manzoni 56, 20089 Rozzano - Milan, Italy. ^[6] Department of Neuroimmunology, Acute Neurology and Pain, Biogen Inc., 115 Broadway, Cambridge, MA, USA. ^[7] Department of Neurology, Washington University, St. Louis, MO, USA. ^[8] Systems and Cell Biology of Neurodegeneration, IREM, University of Zurich, Schlieren, Switzerland. ^[9] Laboratory of Pharmacology and Brain Pathology, Humanitas Clinical and Research Center, Via Manzoni 56, 20089 Rozzano - Milan, Italy; IN-CNR, 20129 Milano, Italy. Electronic address: michela.matteoli@hunimed.eu. ^[10]

关键词 PSD95 TREM2 autism development microglia synapse synaptic pruning