TAR DNA-Binding Protein 43 and Disrupted in Schizophrenia 1 Coaggregation Disrupts Dendritic Local Translation and Mental Function in Frontotemporal Lobar Degeneration.

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第一作者： Ryo,Endo

第一单位： Laboratory for Protein Conformation Diseases, RIKEN Brain Science Institute, Wako, Japan.

作者： Ryo,Endo ^[1] ; Noriko,Takashima ^[1] ; Yoko,Nekooki-Machida ^[1] ; Yusuke,Komi ^[1] ; Kelvin Kai-Wan,Hui ^[1] ; Masaki,Takao ^[2] ; Hiroyasu,Akatsu ^[3] ; Shigeo,Murayama ^[4] ; Akira,Sawa ^[5] ; Motomasa,Tanaka ^[6]

作者单位： Laboratory for Protein Conformation Diseases, RIKEN Brain Science Institute, Wako, Japan. ^[1] Department of Neurology, Saitama Medical University, Moroyama, Saitama, Japan; Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Itabashi-ku, Tokyo, Japan. ^[2] Choju Medical Institute, Fukushimura Hospital, Toyohashi, Japan; Department of Medicine for Aging in Place and Community-Based Medical Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan. ^[3] Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Itabashi-ku, Tokyo, Japan. ^[4] Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD. Electronic address: asawa1@jhmi.edu. ^[5] Laboratory for Protein Conformation Diseases, RIKEN Brain Science Institute, Wako, Japan. Electronic address: motomasa@brain.riken.jp. ^[6]

关键词 Coaggregation DISC1 FTLD Local translation Psychiatric behaviors TDP-43