Hematopoietic Stem Cells but Not Multipotent Progenitors Drive Erythropoiesis during Chronic Erythroid Stress in EPO Transgenic Mice.

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作者： Rashim Pal,Singh ^[1] ; Tatyana,Grinenko ^[1] ; Beáta,Ramasz ^[1] ; Kristin,Franke ^[1] ; Mathias,Lesche ^[2] ; Andreas,Dahl ^[2] ; Max,Gassmann ^[3] ; Triantafyllos,Chavakis ^[4] ; Ian,Henry ^[5] ; Ben,Wielockx ^[6]

作者单位： Institute for Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, Fetscherstraße 74, Dresden 01307, Germany. ^[1] Deep Sequencing Group SFB 655, Biotechnology Center; Technische Universität Dresden, Fetscherstraße 105, Dresden 01307, Germany. ^[2] Institute of Veterinary Physiology, Vetsuisse Faculty and Zurich Center for Integrative Human Physiology (ZIHP), University of Zürich, Winterthurerstr. 190, Zürich 8057, Switzerland; Universidad Peruana Cayetano Heredia (UPCH), Av. Honorio Delgado 430, San Martín de Porres 15102, Peru. ^[3] Institute for Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, Fetscherstraße 74, Dresden 01307, Germany; DFG Research Center and Cluster of Excellence for Regenerative Therapies Dresden, Technische Universität Dresden, Fetscherstraße 105, Dresden 01307, Germany. ^[4] Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraße 108, Dresden 01307, Germany. ^[5] Institute for Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, Fetscherstraße 74, Dresden 01307, Germany; DFG Research Center and Cluster of Excellence for Regenerative Therapies Dresden, Technische Universität Dresden, Fetscherstraße 105, Dresden 01307, Germany. Electronic address: ben.wielockx@tu-dresden.de. ^[6]

关键词 EPO-R bone marrow erythropoietin fate decision hematopoietic stem cell hypoxia progenitors transgenic

主题词动物(Animals);计算生物学(Computational Biology);红系前体细胞(Erythroid Precursor Cells);红细胞生成(Erythropoiesis);红细胞生成素(Erythropoietin);基因表达谱(Gene Expression Profiling);造血干细胞(Hematopoietic Stem Cells);小鼠(Mice);小鼠, 转基因(Mice, Transgenic);应激, 生理学(Stress, Physiological)

DOI 10.1016/j.stemcr.2018.04.012

PMID 29754961

发布时间 2021-01-09

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Stem cell reports

2018年10卷6期

1908-1919页

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Hematopoietic Stem Cells but Not Multipotent Progenitors Drive Erythropoiesis during Chronic Erythroid Stress in EPO Transgenic Mice.

Stem cell reports

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Hematopoietic Stem Cells but Not Multipotent Progenitors Drive Erythropoiesis during Chronic Erythroid Stress in EPO Transgenic Mice.

Stem cell reports

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Stem cell reports

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