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首页> FEMS microbiology letters> CRISPR/Cas9/sgRNA-mediated targeted gene modification confirms the cause-effect relationship between gyrA mutation and quinolone resistance in Escherichia coli.

CRISPR/Cas9/sgRNA-mediated targeted gene modification confirms the cause-effect relationship between gyrA mutation and quinolone resistance in Escherichia coli.

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作者： Haixiang,Qiu ^[1] ; Jiansen,Gong ^[2] ; Patrick,Butaye ^[3] ; Guangwu,Lu ^[4] ; Ke,Huang ^[1] ; Guoqiang,Zhu ^[1] ; Jilei,Zhang ^[1] ; Terri,Hathcock ^[1] ; Darong,Cheng ^[5] ; Chengming,Wang ^[1]

作者单位： Department of Basic Sciences, Yangzhou University College of Veterinary Medicine, Yangzhou, Jiangsu, 225009, PR China. ^[1] Poultry Institute, Chinese Academy of Agricultural Sciences, Yangzhou, Jiangsu, 221003, PR China. ^[2] Department of Biosciences, Ross University School of Veterinary Medicine, P.O. Box 334, Basseterre, St. Kitts, West Indies. ^[3] Department of Pathology, Bacteriology and Poultry Diseases, Faculty of Veterinary Medicine Salisburylaan 133, 9820 Merelbeke, Belgium. ^[4] College of Veterinary Medicine, Auburn University, Auburn, AL, 36849, USA. ^[5]

主题词氨基酸特征结构(Amino Acid Motifs);动物(Animals);抗菌药(Anti-Bacterial Agents);鸡(Chickens);环丙沙星(Ciprofloxacin);DNA促旋酶(DNA Gyrase);抗药性, 细菌(Drug Resistance, Bacterial);大肠杆菌(Escherichia coli);大肠杆菌感染(Escherichia coli Infections);大肠杆菌蛋白质类(Escherichia coli Proteins);微生物敏感性试验(Microbial Sensitivity Tests);突变(Mutation);家禽疾病(Poultry Diseases);喹啉类(Quinolines);喹诺酮类(Quinolones);RNA, 细菌(RNA, Bacterial);猪(Swine);猪疾病(Swine Diseases)

DOI 10.1093/femsle/fny127

PMID 29767711

发布时间 2019-09-18

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FEMS microbiology letters

FEMS microbiology letters

2018年365卷13期

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