Aberrant modulation of ribosomal protein S6 phosphorylation confers acquired resistance to MAPK pathway inhibitors in BRAF-mutant melanoma.

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第一作者： Ming-Zhao,Gao

第一单位： Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.;University of Chinese Academy of Sciences, Beijing, 100049, China.

作者： Ming-Zhao,Gao ^[1] ; Hong-Bin,Wang ^[1] ; Xiang-Ling,Chen ^[1] ; Wen-Ting,Cao ^[2] ; Li,Fu ^[2] ; Yun,Li ^[2] ; Hai-Tian,Quan ^[1] ; Cheng-Ying,Xie ^[3] ; Li-Guang,Lou ^[4]

作者单位： Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.;University of Chinese Academy of Sciences, Beijing, 100049, China. ^[1] Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. ^[2] Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. xiechengying818@simm.ac.cn.;University of Chinese Academy of Sciences, Beijing, 100049, China. xiechengying818@simm.ac.cn. ^[3] Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. lglou@mail.shcnc.ac.cn.;University of Chinese Academy of Sciences, Beijing, 100049, China. lglou@mail.shcnc.ac.cn. ^[4]

关键词 BRAF-mutant melanoma G1/G0 phase arrest MAPK pathway inhibitors P70S6K RSK acquired resistance mTOR inhibitor rpS6