Nimbolide epigenetically regulates autophagy and apoptosis in breast cancer.

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第一作者： Venkatesh,Pooladanda

第一单位： Department of Regulatory Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Balanagar, Hyderabad, Telangana 500037, India.

作者： Venkatesh,Pooladanda ^[1] ; Soumya,Bandi ^[2] ; Sandhya Rani,Mondi ^[2] ; Krishna Mohan,Gottumukkala ^[2] ; Chandraiah,Godugu ^[3]

作者单位： Department of Regulatory Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Balanagar, Hyderabad, Telangana 500037, India. ^[1] Centre for Pharmaceutical Sciences, Institute of Science and Technology, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad, Telangana 500085, India. ^[2] Department of Regulatory Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Balanagar, Hyderabad, Telangana 500037, India. Electronic address: chandra.niperhyd@gov.in. ^[3]

关键词 Apoptosis Autophagy H3K27Ac HDAC-2 Nimbolide

主题词乙酰化作用(Acetylation);抗肿瘤药(Antineoplastic Agents);细胞凋亡(Apoptosis);自噬(Autophagy);乳腺肿瘤(Breast Neoplasms);细胞系, 肿瘤(Cell Line, Tumor);细胞存活(Cell Survival);后成说, 遗传(Epigenesis, Genetic);组蛋白脱乙酰基酶2(Histone Deacetylase 2);组蛋白类(Histones);人类(Humans);柠檬苦素类(Limonins);膜电位, 线粒体(Membrane Potential, Mitochondrial);微管相关蛋白质类(Microtubule-Associated Proteins);原癌基因蛋白质c-bcl-2(Proto-Oncogene Proteins c-bcl-2);RNA结合蛋白质类(RNA-Binding Proteins);信号传导(Signal Transduction);TOR丝氨酸-苏氨酸激酶(TOR Serine-Threonine Kinases)

DOI 10.1016/j.tiv.2018.05.010

PMID 29778718

发布时间 2021-12-04

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Toxicology in vitro

2018年51卷

114-128页

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Nimbolide epigenetically regulates autophagy and apoptosis in breast cancer.

Toxicology in vitro

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Nimbolide epigenetically regulates autophagy and apoptosis in breast cancer.

Toxicology in vitro

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Toxicology in vitro

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