Common and unique transcriptional responses to dietary restriction and loss of insulin receptor substrate 1 (IRS1) in mice.

导出 OA

翻译打印收藏纠错

作者： Melissa M,Page ^[1] ; Eugene F,Schuster ^[2] ; Manikhandan,Mudaliar ^[3] ; Pawel,Herzyk ^[4] ; Dominic J,Withers ^[5] ; Colin,Selman ^[6]

作者单位： Institute des Sciences de la Vie, Faculty of Sciences, Université Catholique de Louvain, Louvain-la-Neuve, Belgium. ^[1] The Breast Cancer Now Toby Robins Research Centre The Institute of Cancer Research, London, UK. ^[2] Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK. ^[3] Glasgow Molecular Pathology Node, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK. ^[4] Present address: Cerevance, Cambridge Science Park, Cambridge, UK. ^[5] Glasgow Polyomics, Wolfson Wohl Cancer Research Centre, University of Glasgow, Garscube Campus, Bearsden, UK. ^[6] Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK. ^[7] MRC London Institute of Medical Sciences, London, UK. ^[8] Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK. ^[9] Glasgow Ageing Research Network (GARNER), Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK. ^[10]

关键词 dietary restriction insulin receptor substrate 1 insulin/IGF-1 signalling lifespan transcriptomics

主题词动物(Animals);热量限制(Caloric Restriction);胰岛素受体底物蛋白质类(Insulin Receptor Substrate Proteins);长寿(Longevity);小鼠(Mice);小鼠, 基因敲除(Mice, Knockout);转录, 遗传(Transcription, Genetic)

DOI 10.18632/aging.101446

PMID 29779018

发布时间 2022-01-29

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交