Molecular elements in FGF19 and FGF21 defining KLB/FGFR activity and specificity.

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第一作者： Archita,Agrawal

第一单位： Department of Chemistry, Indiana University, Bloomington, IN, 47405, USA; Interdisciplinary Biochemistry Graduate Program, Indiana University, Bloomington, IN, 47405, USA.

作者： Archita,Agrawal ^[1] ; Sebastian,Parlee ^[2] ; Diego,Perez-Tilve ^[3] ; Pengyun,Li ^[2] ; Jia,Pan ^[2] ; Piotr A,Mroz ^[4] ; Ann Maria,Kruse Hansen ^[5] ; Birgitte,Andersen ^[5] ; Brian,Finan ^[2] ; Alexei,Kharitonenkov ^[6] ; Richard D,DiMarchi ^[7]

作者单位： Department of Chemistry, Indiana University, Bloomington, IN, 47405, USA; Interdisciplinary Biochemistry Graduate Program, Indiana University, Bloomington, IN, 47405, USA. ^[1] Novo Nordisk Research Center Indianapolis, Indianapolis, IN, 46241, USA. ^[2] Metabolic Diseases Institute, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA. ^[3] Department of Chemistry, Indiana University, Bloomington, IN, 47405, USA. ^[4] Global Research, Novo Nordisk A/S, Novo Nordisk Park, Måløv, DK-2760, Denmark. ^[5] Novo Nordisk Research Center Indianapolis, Indianapolis, IN, 46241, USA. Electronic address: alexkhar@indiana.edu. ^[6] Department of Chemistry, Indiana University, Bloomington, IN, 47405, USA; Interdisciplinary Biochemistry Graduate Program, Indiana University, Bloomington, IN, 47405, USA; Novo Nordisk Research Center Indianapolis, Indianapolis, IN, 46241, USA. Electronic address: rdimarch@indiana.edu. ^[7]

关键词 Alanine-scan FGF antagonism FGF19 FGF21 FGFR isoforms KLB Structure-activity-relationship

主题词氨基酸序列(Amino Acid Sequence);动物(Animals);成纤维细胞生长因子(Fibroblast Growth Factors);葡糖醛酸糖苷酶(Glucuronidase);HEK293细胞(HEK293 Cells);人类(Humans);肝(Liver);男(雄)性(Male);膜蛋白质类(Membrane Proteins);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 肥胖(Mice, Obese);肽类(Peptides);磷酰化(Phosphorylation);受体, 成纤维细胞生长因子, 1型(Receptor, Fibroblast Growth Factor, Type 1);信号传导(Signal Transduction)

DOI 10.1016/j.molmet.2018.05.003

PMID 29789271

发布时间 2021-12-04

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Molecular metabolism

2018年13卷

45-55页

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Molecular elements in FGF19 and FGF21 defining KLB/FGFR activity and specificity.

Molecular metabolism

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Molecular elements in FGF19 and FGF21 defining KLB/FGFR activity and specificity.

Molecular metabolism

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Molecular metabolism

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