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首页> BMC cancer> Involvement of the CB<sub>2</sub> cannabinoid receptor in cell growth inhibition and G0/G1 cell cycle arrest via the cannabinoid agonist WIN 55,212-2 in renal cell carcinoma.

Involvement of the CB<sub>2</sub> cannabinoid receptor in cell growth inhibition and G0/G1 cell cycle arrest via the cannabinoid agonist WIN 55,212-2 in renal cell carcinoma.

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作者： Mohammed I,Khan ^[1] ; Anna A,Sobocińska ^[2] ; Klaudia K,Brodaczewska ^[3] ; Katarzyna,Zielniok ^[4] ; Malgorzata,Gajewska ^[3] ; Claudine,Kieda ^[5] ; Anna M,Czarnecka ^[5] ; Cezary,Szczylik ^[3]

作者单位： Molecular Oncology Laboratory, Department of Oncology, Military Institute of Medicine, ul. Szaserów 128, 04-141, Warsaw, Poland. imrankhanbioinfo@gmail.com. ^[1] Department of Otolaryngology - Head & Neck Surgery, Western University, London, ON, N6A 3K7, Canada. imrankhanbioinfo@gmail.com. ^[2] Molecular Oncology Laboratory, Department of Oncology, Military Institute of Medicine, ul. Szaserów 128, 04-141, Warsaw, Poland. ^[3] Faculty of Biology, Warsaw University, ul. Miecznikowa 1, 02-096, Warsaw, Poland. ^[4] Department of Physiological Sciences, Warsaw University of Life Sciences-SGGW, Nowoursynowska 159, 02-776, Warsaw, Poland. ^[5] Warsaw Medical University, Żwirki i Wigury 61, 02-091, Warsaw, Poland. ^[6]

关键词 CB1 and CB2 receptors Endocannabinoid system (ECS)JWH-133 Renal cell carcinoma WIN 55,212–2 mesylate

主题词细胞凋亡(Apoptosis);苯并恶嗪类(Benzoxazines);癌, 肾细胞(Carcinoma, Renal Cell);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);药物筛选试验, 抗肿瘤(Drug Screening Assays, Antitumor);人类(Humans);肾肿瘤(Kidney Neoplasms);吗啉类(Morpholines);萘类(Naphthalenes);受体, 大麻酚, CB1(Receptor, Cannabinoid, CB1);受体, 大麻酚, CB2(Receptor, Cannabinoid, CB2);信号传导(Signal Transduction)

DOI 10.1186/s12885-018-4496-1

PMID 29792186

发布时间 2022-04-09

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BMC cancer

BMC cancer

2018年18卷1期

583页

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