Synthesis of aryl pyrazole via Suzuki coupling reaction, in vitro mushroom tyrosinase enzyme inhibition assay and in silico comparative molecular docking analysis with Kojic acid.

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作者： Pervaiz Ali,Channar ^[1] ; Aamer,Saeed ^[2] ; Fayaz Ali,Larik ^[3] ; Bakhtawar,Batool ^[1] ; Saima,Kalsoom ^[4] ; M M,Hasan ^[5] ; Mauricio F,Erben ^[6] ; Hesham R,El-Seedi ^[7] ; Musrat,Ali ^[8] ; Zaman,Ashraf ^[9]

作者单位： Department of Chemistry, Quaid-i-Azam University, 45320 Islamabad, Pakistan. ^[1] Department of Chemistry, Quaid-i-Azam University, 45320 Islamabad, Pakistan. Electronic address: aamersaeed@yahoo.com. ^[2] Department of Chemistry, Quaid-i-Azam University, 45320 Islamabad, Pakistan. Electronic address: fayazali@chem.qau.edu.pk. ^[3] SA-CIRBS, International Islamic University, Islamabad, Pakistan. ^[4] Pakistan Institute of Engineering and Applied Sciences, PIEAS, Pakistan. ^[5] CEQUINOR (UNLP, CONICET-CCT La Plata), Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, C.C. 962, La Plata 1900, Argentina. ^[6] Division of Pharmacognosy, Department of Medicinal Chemistry, Uppsala University, Biomedical Centre, Box 574, SE-751 23 Uppsala, Sweden. ^[7] Department of Biological Sciences, Quaid-i-Azam University, 45320 Islamabad, Pakistan. ^[8] Department of Chemistry, Allama Iqbal Open University, Islamabad 44000, Pakistan. ^[9]

关键词 Aryl pyrazoles In silico Molecular docking studies In vitro Mushroom tyrosinase assay Kojic acid Suzuki cross coupling