Novel substituted pyrazolone derivatives as AMP-activated protein kinase activators to inhibit lipid synthesis and reduce lipid accumulation in ob/ob mice.

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第一作者： Mei,Zhang

第一单位： State Key Laboratory of Drug Research, the National Drug Screening Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.

作者： Mei,Zhang ^[1] ; Zhi-Fu,Xie ^[2] ; Run-Tao,Zhang ^[1] ; Da-Kai,Chen ^[1] ; Min,Gu ^[1] ; Shi-Chao,Cui ^[1] ; Yang-Ming,Zhang ^[1] ; Xin-Wen,Zhang ^[1] ; Yan-Yan,Yu ^[1] ; Jia,Li ^[1] ; Fa-Jun,Nan ^[3] ; Jing-Ya,Li ^[4]

作者单位： State Key Laboratory of Drug Research, the National Drug Screening Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. ^[1] State Key Laboratory of Drug Research, the National Drug Screening Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.;University of Chinese Academy of Sciences, Beijing, 100049, China. ^[2] State Key Laboratory of Drug Research, the National Drug Screening Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. fjnan@simm.ac.cn. ^[3] State Key Laboratory of Drug Research, the National Drug Screening Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. jyli@simm.ac.cn. ^[4]

关键词 AMP-activated protein kinase AMPK activator homogeneous time-resolved fluorescence metabolic disorders non-alcoholic fatty liver disease ob/ob micer