Co-crystal of Tramadol-Celecoxib in Patients with Moderate to Severe Acute Post-surgical Oral Pain: A Dose-Finding, Randomised, Double-Blind, Placebo- and Active-Controlled, Multicentre, Phase II Trial.

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作者： José,López-Cedrún ^[1] ; Sebastián,Videla ^[2] ; Miguel,Burgueño ^[3] ; Inma,Juárez ^[4] ; Samir,Aboul-Hosn ^[5] ; Rafael,Martín-Granizo ^[6] ; Joan,Grau ^[7] ; Miguel,Puche ^[8] ; José-Luis,Gil-Diez ^[9] ; José-Antonio,Hueto ^[10] ; Anna,Vaqué ^[11] ; Mariano,Sust ^[12] ; Carlos,Plata-Salamán ^[12] ; Antoni,Monner ^[12] ; Co-Crystal of Tramadol-Celecoxib Team ^[5]

作者单位： Department of Maxillofacial Surgery, Complexo Hospitalario Universitario A Coruña, A Coruña, Spain. ^[1] Clinical Investigation Department, Laboratorios del Dr. Esteve, S.A.U., Av Mare de Déu de Montserrat 221, 08041, Barcelona, Spain. svidelaces@gmail.com. ^[2] Clinical Research Support Unit, Clinical Pharmacology Department, Bellvitge University Hospital/IDIBELL, Barcelona, Spain. svidelaces@gmail.com. ^[3] Maxillofacial Surgery Unit, Hospital Universitario La Paz, Madrid, Spain. ^[4] Department of Oral and Maxillofacial Surgery, Hospital Universitari de Bellvitge, Barcelona, Spain. ^[5] Department of Maxillofacial Surgery, Hospital Plató, Barcelona, Spain. ^[6] Department of Maxillofacial Surgery, Hospital Clínico San Carlos, Madrid, Spain. ^[7] Department of Maxillofacial Surgery, Hospital General de Granollers, Granollers, Spain. ^[8] Department of Maxillofacial Surgery, Hospital Clínico de Valencia, Valencia, Spain. ^[9] Department of Maxillofacial Surgery, Hospital Universitario La Princesa, Madrid, Spain. ^[10] Maxillofacial Surgery Unit, Hospital Universitari Vall d'Hebron, Barcelona, Spain. ^[11] Clinical Investigation Department, Laboratorios del Dr. Esteve, S.A.U., Av Mare de Déu de Montserrat 221, 08041, Barcelona, Spain. ^[12]