Low incidence of SNVs and indels in trio genomes of Cas9-mediated multiplex edited sheep.

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第一作者： Xiaolong,Wang

第一单位： College of Animal Science and Technology, Yangling, 712100, China.

作者： Xiaolong,Wang ^[1] ; Jing,Liu ^[1] ; Yiyuan,Niu ^[1] ; Yan,Li ^[1] ; Shiwei,Zhou ^[1] ; Chao,Li ^[1] ; Baohua,Ma ^[2] ; Qifang,Kou ^[3] ; Bjoern,Petersen ^[4] ; Tad,Sonstegard ^[5] ; Xingxu,Huang ^[6] ; Yu,Jiang ^[7] ; Yulin,Chen ^[8]

作者单位： College of Animal Science and Technology, Yangling, 712100, China. ^[1] College of Veterinary Medicine, Northwest A&F University, Yangling, 712100, China. ^[2] Ningxia Tianyuan Tan Sheep Farm, Hongsibu, 751999, China. ^[3] Institute of Farm Animal Genetics, Friedrich-Loeffler-Institut, 31535, Neustadt, Germany. ^[4] Recombinetics, St. Paul, Minneapolis, MN, 55104, USA. ^[5] School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China. huangxx@shanghaitech.edu.cn. ^[6] College of Animal Science and Technology, Yangling, 712100, China. yu.jiang@nwafu.edu.cn. ^[7] College of Animal Science and Technology, Yangling, 712100, China. chenyulin@nwafu.edu.cn. ^[8]

关键词 CRISPR/Cas9 Genome editing Off-target; mutation rate Sheep Whole genome sequencing

主题词动物(Animals);基因组学(Genomics);INDEL突变(INDEL Mutation);多态性, 单核苷酸(Polymorphism, Single Nucleotide);绵羊(Sheep)

DOI 10.1186/s12864-018-4712-z

PMID 29801435

发布时间 2018-12-18

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