The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma.-论文-万方医学网

第一作者： Bill H,Diplas

第一单位： The Preston Robert Tisch Brain Tumor Center at Duke, Duke University Medical Center, Durham, 27710, NC, USA.;Department of Pathology, Duke University Medical Center, Durham, 27710, NC, USA.

作者： Bill H,Diplas ^[1] ; Xujun,He ^[2] ; Jacqueline A,Brosnan-Cashman ^[3] ; Heng,Liu ^[1] ; Lee H,Chen ^[1] ; Zhaohui,Wang ^[1] ; Casey J,Moure ^[1] ; Patrick J,Killela ^[1] ; Daniel B,Loriaux ^[1] ; Eric S,Lipp ^[4] ; Paula K,Greer ^[1] ; Rui,Yang ^[1] ; Anthony J,Rizzo ^[3] ; Fausto J,Rodriguez ^[3] ; Allan H,Friedman ^[5] ; Henry S,Friedman ^[4] ; Sizhen,Wang ^[6] ; Yiping,He ^[1] ; Roger E,McLendon ^[1] ; Darell D,Bigner ^[5] ; Yuchen,Jiao ^[7] ; Matthew S,Waitkus ^[8] ; Alan K,Meeker ^[9] ; Hai,Yan ^[10]

作者单位： The Preston Robert Tisch Brain Tumor Center at Duke, Duke University Medical Center, Durham, 27710, NC, USA.;Department of Pathology, Duke University Medical Center, Durham, 27710, NC, USA. ^[1] The Preston Robert Tisch Brain Tumor Center at Duke, Duke University Medical Center, Durham, 27710, NC, USA.;Department of Pathology, Duke University Medical Center, Durham, 27710, NC, USA.;Key Laboratory of Gastroenterology of Zhejiang Province, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China. ^[2] Department of Pathology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, 21231, MD, USA. ^[3] The Preston Robert Tisch Brain Tumor Center at Duke, Duke University Medical Center, Durham, 27710, NC, USA. ^[4] The Preston Robert Tisch Brain Tumor Center at Duke, Duke University Medical Center, Durham, 27710, NC, USA.;Department of Neurosurgery, Duke University Medical Center, Durham, 27710, NC, USA. ^[5] Genetron Health (Beijing) Co. Ltd, Beijing, 102208, China. ^[6] State Key Laboratory of Molecular Oncology, Laboratory of Cell and Molecular Biology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China. jiaoyuchen@cicams.ac.cn. ^[7] The Preston Robert Tisch Brain Tumor Center at Duke, Duke University Medical Center, Durham, 27710, NC, USA. matthew.waitkus@duke.edu.;Department of Pathology, Duke University Medical Center, Durham, 27710, NC, USA. matthew.waitkus@duke.edu. ^[8] Department of Pathology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, 21231, MD, USA. ameeker1@jhmi.edu. ^[9] The Preston Robert Tisch Brain Tumor Center at Duke, Duke University Medical Center, Durham, 27710, NC, USA. hai.yan@duke.edu.;Department of Pathology, Duke University Medical Center, Durham, 27710, NC, USA. hai.yan@duke.edu. ^[10]

医学主题词青少年(Adolescent);成年人(Adult);老年人(Aged);老年人, 80以上(Aged, 80 and over);脑肿瘤(Brain Neoplasms);细胞系, 肿瘤(Cell Line, Tumor);DNA解旋酶类(DNA Helicases);女(雌)性(Female);基因组学(Genomics);胶质母细胞瘤(Glioblastoma);HEK293细胞(HEK293 Cells);人类(Humans);异柠檬酸脱氢酶(Isocitrate Dehydrogenase);男(雄)性(Male);中年人(Middle Aged);突变(Mutation);启动区, 遗传(Promoter Regions, Genetic);存活率分析(Survival Analysis);末端转移酶端粒(Telomerase);青年人(Young Adult)

DOI 10.1038/s41467-018-04448-6

PMID 29802247

发布时间 2026-04-02

基金项目

F30 CA206423/CA/NCI NIH HHS/United States T32 CA009110/CA/NCI NIH HHS/United States R01 CA140316/CA/NCI NIH HHS/United States R01 NS101074/NS/NINDS NIH HHS/United States P30 CA014236/CA/NCI NIH HHS/United States T32 GM007171/GM/NIGMS NIH HHS/United States R01 NS096407/NS/NINDS NIH HHS/United States T32 HD040372/HD/NICHD NIH HHS/United States

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The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma.

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The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma.

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