Characterization of mannitol granules and powder: A comparative study using two flowability testers.

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第一作者： Yoshiko,Takeuchi

第一单位： Laboratory of Pharmaceutical Engineering, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, Japan. Electronic address: takeuchiy@gifu-pu.ac.jp.

作者： Yoshiko,Takeuchi ^[1] ; Tomoka,Tomita ^[2] ; Junko,Kuroda ^[2] ; Akihiro,Kageyu ^[2] ; Chihiro,Yonekura ^[2] ; Yukiyoshi,Hiramura ^[3] ; Kohei,Tahara ^[2] ; Hirofumi,Takeuchi ^[2]

作者单位： Laboratory of Pharmaceutical Engineering, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, Japan. Electronic address: takeuchiy@gifu-pu.ac.jp. ^[1] Laboratory of Pharmaceutical Engineering, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, Japan. ^[2] Malvern Instruments, A Division of Spectris Co., Ltd., Japan, 2-6, Kanda-tukasamachi, Chiyoda-ku, Tokyo, Japan. ^[3]

关键词 Carr’s index Dynamic flow Flowability tester Mannitol granules Powder flow Shear test

主题词辅药(Excipients);甘露醇(Mannitol);粒子大小(Particle Size);粉剂(Powders);流变学(Rheology)

DOI 10.1016/j.ijpharm.2018.05.061

PMID 29803796

发布时间 2018-10-15

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