An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion.

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作者： Christian,Baumgartner ^[1] ; Stefanie,Toifl ^[1] ; Matthias,Farlik ^[2] ; Florian,Halbritter ^[2] ; Ruth,Scheicher ^[3] ; Irmgard,Fischer ^[1] ; Veronika,Sexl ^[3] ; Christoph,Bock ^[4] ; Manuela,Baccarini ^[5]

作者单位： Department of Microbiology, Immunobiology and Genetics, Center for Molecular Biology of the University of Vienna, Max F. Perutz Laboratories, Vienna Biocenter (VBC), 1030 Vienna, Austria. ^[1] CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria. ^[2] Department for Biomedical Sciences, Institute of Pharmacology and Toxicology, University of Veterinary Medicine, 1210 Vienna, Austria. ^[3] CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria; Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria; Saarland Informatics Campus, Max Planck Institute for Informatics, Saarbrücken, Germany. ^[4] Department of Microbiology, Immunobiology and Genetics, Center for Molecular Biology of the University of Vienna, Max F. Perutz Laboratories, Vienna Biocenter (VBC), 1030 Vienna, Austria. Electronic address: manuela.baccarini@univie.ac.at. ^[5]

关键词 AKT/mTORC1 pathway ERK pathway emergency hematopoiesis feedback regulation of signaling hematopoietic stem cell activation hematopoietic stem cell exhaustion hematopoietic stem cells intracellular signaling mitochondrial fitness oxidative stress