A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin.

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作者： Grégory,Menchon ^[1] ; Andrea E,Prota ^[1] ; Daniel,Lucena-Agell ^[2] ; Pascal,Bucher ^[3] ; Rolf,Jansen ^[4] ; Herbert,Irschik ^[4] ; Rolf,Müller ^[5] ; Ian,Paterson ^[6] ; J Fernando,Díaz ^[2] ; Karl-Heinz,Altmann ^[3] ; Michel O,Steinmetz ^[7]

作者单位： Laboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institut, Villigen PSI, 5232, Switzerland. ^[1] Chemical and Physical Biology, Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Cientificas CIB-CSIC, Madrid, 28040, Spain. ^[2] Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zürich, Zürich, 8093, Switzerland. ^[3] Abteilung Mikrobielle Wirkstoffe, Helmholtz Zentrum für Infektionsforschung, Braunschweig, 38124, Germany. ^[4] Department Microbial Natural Products and Department of Pharmacy at Saarland University, Helmholtz Institute for Pharmaceutical Research Saarland, Helmholtz Centre for Infection Research, Saarbrücken, 66123, Germany. ^[5] University Chemical Laboratory, Cambridge University, Cambridge, CB2 1EW, UK. ^[6] Laboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institut, Villigen PSI, 5232, Switzerland. michel.steinmetz@psi.ch. ^[7] University of Basel, Biozentrum, Basel, 4056, Switzerland. michel.steinmetz@psi.ch. ^[8]