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首页> Cell reports> Antigenic Variation in the Lyme Spirochete: Insights into Recombinational Switching with a Suggested Role for Error-Prone Repair.

Antigenic Variation in the Lyme Spirochete: Insights into Recombinational Switching with a Suggested Role for Error-Prone Repair.

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作者： Theodore B,Verhey ^[1] ; Mildred,Castellanos ^[1] ; George,Chaconas ^[2]

作者单位： Department of Biochemistry and Molecular Biology, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada. ^[1] Department of Biochemistry and Molecular Biology, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada; Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada. Electronic address: chaconas@ucalgary.ca. ^[2]

关键词 Borrelia burgdorferi, Lyme disease antigenic variation error-prone repair expression locus segmental gene conversion silent cassettes vlsE

主题词动物(Animals);抗原变异(Antigenic Variation);伯氏疏螺旋体(Borrelia burgdorferi);基因座(Genetic Loci);INDEL突变(INDEL Mutation);免疫球蛋白类别转换(Immunoglobulin Class Switching);莱姆病(Lyme Disease);小鼠, SCID(Mice, SCID);多态性, 单核苷酸(Polymorphism, Single Nucleotide);重组, 遗传(Recombination, Genetic);序列同源性, 氨基酸(Sequence Homology, Amino Acid);模板, 遗传(Templates, Genetic)

DOI 10.1016/j.celrep.2018.04.117

PMID 29847791

发布时间 2019-11-05

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Cell reports

Cell reports

2018年23卷9期

2595-2605页

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