作者:
Hervé,Tiriac [1]
;
Pascal,Belleau [1]
;
Dannielle D,Engle [1]
;
Dennis,Plenker [1]
;
Astrid,Deschênes [1]
;
Tim D D,Somerville [1]
;
Fieke E M,Froeling [1]
;
Richard A,Burkhart [2]
;
Robert E,Denroche [3]
;
Gun-Ho,Jang [3]
;
Koji,Miyabayashi [1]
;
C Megan,Young [1]
;
Hardik,Patel [4]
;
Michelle,Ma [1]
;
Joseph F,LaComb [1]
;
Randze Lerie D,Palmaira [5]
;
Ammar A,Javed [6]
;
Jasmine C,Huynh [2]
;
Molly,Johnson [7]
;
Kanika,Arora [8]
;
Nicolas,Robine [8]
;
Minita,Shah [8]
;
Rashesh,Sanghvi [8]
;
Austin B,Goetz [8]
;
Cinthya Y,Lowder [9]
;
Laura,Martello [9]
;
Else,Driehuis [10]
;
Nicolas,LeComte [11]
;
Gokce,Askan [12]
;
Christine A,Iacobuzio-Donahue [6]
;
Hans,Clevers [6]
;
Laura D,Wood [6]
;
Ralph H,Hruban [11]
;
Elizabeth,Thompson [12]
;
Andrew J,Aguirre [13]
;
Brian M,Wolpin [14]
;
Aaron,Sasson [14]
;
Joseph,Kim [14]
;
Maoxin,Wu [15]
;
Juan Carlos,Bucobo [15]
;
Peter,Allen [16]
;
Divyesh V,Sejpal [16]
;
William,Nealon [17]
;
James D,Sullivan [5]
;
Jordan M,Winter [6]
;
Phyllis A,Gimotty [18]
;
Jean L,Grem [19]
;
Dominick J,DiMaio [19]
;
Jonathan M,Buscaglia [9]
;
Paul M,Grandgenett [20]
;
Jonathan R,Brody [21]
;
Michael A,Hollingsworth [22]
;
Grainne M,O'Kane [5]
;
Faiyaz,Notta [23]
;
Edward,Kim [9]
;
James M,Crawford [23]
;
Craig,Devoe [24]
;
Allyson,Ocean [3]
;
Christopher L,Wolfgang [7]
;
Kenneth H,Yu [25]
;
Ellen,Li [26]
;
Christopher R,Vakoc [27]
;
Benjamin,Hubert [2]
;
Sandra E,Fischer [6]
;
Julie M,Wilson [5]
;
Richard,Moffitt [1]
;
Jennifer,Knox [8]
;
Alexander,Krasnitz [28]
;
Steven,Gallinger [29]
;
David A,Tuveson [3]
作者单位:
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.
[1]
Johns Hopkins University, Division of Hepatobiliary and Pancreatic Surgery, Baltimore, Maryland.
[2]
PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
[3]
Swiss Federal Institute of Technology Lausanne (EPFL), School of Life Sciences, Swiss Institute for Experimental Cancer Research (ISREC), Laboratory of Tumor Heterogeneity and Stemness in Cancer, Lausanne, Switzerland.
[4]
Department of Medicine, Stony Brook University, Stony Brook, New York.
[5]
Memorial Sloan Kettering Cancer Center, New York, New York.
[6]
University of California, Davis, Comprehensive Cancer Center, Division of Hematology and Oncology, Sacramento, California.
[7]
New York Genome Center, New York, New York.
[8]
Department of Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania.
[9]
SUNY Downstate Medical Center, Department of Medicine, New York, New York.
[10]
Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), Utrecht, the Netherlands.
[11]
University Medical Center (UMC), Utrecht, the Netherlands.
[12]
Princess Maxime Center (PMC), Utrecht, the Netherlands.
[13]
Department of Pathology, Johns Hopkins University, Baltimore, Maryland.
[14]
Dana-Farber Cancer Institute, Broad Institute, Boston, Massachusetts.
[15]
Department of Surgery, Stony Brook University, Stony Brook, New York.
[16]
Department of Pathology, Stony Brook University, Stony Brook, New York.
[17]
Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Division of Gastroenterology, Hempstead, New York.
[18]
Department of Surgery, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York.
[19]
Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania.
[20]
Department of Medicine, University of Nebraska Medical Center, Omaha, Nebraska.
[21]
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska.
[22]
University of Nebraska Medical Center, Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffet Cancer Center, Omaha, Nebraska.
[23]
Wallace McCain Centre for Pancreatic Cancer, Department of Medical Oncology, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada.
[24]
Department of Pathology and Laboratory Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York.
[25]
Division of Medical Oncology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York.
[26]
Weill Cornell Medical College, New York, New York.
[27]
Department of Pathology, University Health Network, University of Toronto, Toronto, Ontario, Canada.
[28]
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
[29]
Department of Biomedical Informatics, Stony Brook University, Stony Brook, New York.
[30]
PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, Ontario, Canada. dtuveson@cshl.edu steven.gallinger@uhn.ca.
[31]
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
[32]
Hepatobiliary/Pancreatic Surgical Oncology Program, University Health Network, Toronto, Ontario, Canada.
[33]
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York. dtuveson@cshl.edu steven.gallinger@uhn.ca.
[34]
主题词
抗肿瘤药(Antineoplastic Agents);抗药性, 肿瘤(Drug Resistance, Neoplasm);药物筛选试验, 抗肿瘤(Drug Screening Assays, Antitumor);基因表达谱(Gene Expression Profiling);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);基因调控网络(Gene Regulatory Networks);人类(Humans);分子靶向治疗(Molecular Targeted Therapy);类器官(Organoids);胰腺肿瘤(Pancreatic Neoplasms);前瞻性研究(Prospective Studies);序列分析, RNA(Sequence Analysis, RNA);护理标准(Standard of Care);肿瘤细胞, 培养的(Tumor Cells, Cultured)
DOI
10.1158/2159-8290.CD-18-0349
PMID
29853643
发布时间
2022-07-16
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Cancer discovery
Cancer discovery
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