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Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer.

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作者: Hervé,Tiriac [1] ; Pascal,Belleau [1] ; Dannielle D,Engle [1] ; Dennis,Plenker [1] ; Astrid,Deschênes [1] ; Tim D D,Somerville [1] ; Fieke E M,Froeling [1] ; Richard A,Burkhart [2] ; Robert E,Denroche [3] ; Gun-Ho,Jang [3] ; Koji,Miyabayashi [1] ; C Megan,Young [1] ; Hardik,Patel [4] ; Michelle,Ma [1] ; Joseph F,LaComb [1] ; Randze Lerie D,Palmaira [5] ; Ammar A,Javed [6] ; Jasmine C,Huynh [2] ; Molly,Johnson [7] ; Kanika,Arora [8] ; Nicolas,Robine [8] ; Minita,Shah [8] ; Rashesh,Sanghvi [8] ; Austin B,Goetz [8] ; Cinthya Y,Lowder [9] ; Laura,Martello [9] ; Else,Driehuis [10] ; Nicolas,LeComte [11] ; Gokce,Askan [12] ; Christine A,Iacobuzio-Donahue [6] ; Hans,Clevers [6] ; Laura D,Wood [6] ; Ralph H,Hruban [11] ; Elizabeth,Thompson [12] ; Andrew J,Aguirre [13] ; Brian M,Wolpin [14] ; Aaron,Sasson [14] ; Joseph,Kim [14] ; Maoxin,Wu [15] ; Juan Carlos,Bucobo [15] ; Peter,Allen [16] ; Divyesh V,Sejpal [16] ; William,Nealon [17] ; James D,Sullivan [5] ; Jordan M,Winter [6] ; Phyllis A,Gimotty [18] ; Jean L,Grem [19] ; Dominick J,DiMaio [19] ; Jonathan M,Buscaglia [9] ; Paul M,Grandgenett [20] ; Jonathan R,Brody [21] ; Michael A,Hollingsworth [22] ; Grainne M,O'Kane [5] ; Faiyaz,Notta [23] ; Edward,Kim [9] ; James M,Crawford [23] ; Craig,Devoe [24] ; Allyson,Ocean [3] ; Christopher L,Wolfgang [7] ; Kenneth H,Yu [25] ; Ellen,Li [26] ; Christopher R,Vakoc [27] ; Benjamin,Hubert [2] ; Sandra E,Fischer [6] ; Julie M,Wilson [5] ; Richard,Moffitt [1] ; Jennifer,Knox [8] ; Alexander,Krasnitz [28] ; Steven,Gallinger [29] ; David A,Tuveson [3]
作者单位: Cold Spring Harbor Laboratory, Cold Spring Harbor, New York. [1] Johns Hopkins University, Division of Hepatobiliary and Pancreatic Surgery, Baltimore, Maryland. [2] PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, Ontario, Canada. [3] Swiss Federal Institute of Technology Lausanne (EPFL), School of Life Sciences, Swiss Institute for Experimental Cancer Research (ISREC), Laboratory of Tumor Heterogeneity and Stemness in Cancer, Lausanne, Switzerland. [4] Department of Medicine, Stony Brook University, Stony Brook, New York. [5] Memorial Sloan Kettering Cancer Center, New York, New York. [6] University of California, Davis, Comprehensive Cancer Center, Division of Hematology and Oncology, Sacramento, California. [7] New York Genome Center, New York, New York. [8] Department of Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania. [9] SUNY Downstate Medical Center, Department of Medicine, New York, New York. [10] Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), Utrecht, the Netherlands. [11] University Medical Center (UMC), Utrecht, the Netherlands. [12] Princess Maxime Center (PMC), Utrecht, the Netherlands. [13] Department of Pathology, Johns Hopkins University, Baltimore, Maryland. [14] Dana-Farber Cancer Institute, Broad Institute, Boston, Massachusetts. [15] Department of Surgery, Stony Brook University, Stony Brook, New York. [16] Department of Pathology, Stony Brook University, Stony Brook, New York. [17] Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Division of Gastroenterology, Hempstead, New York. [18] Department of Surgery, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York. [19] Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania. [20] Department of Medicine, University of Nebraska Medical Center, Omaha, Nebraska. [21] Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska. [22] University of Nebraska Medical Center, Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffet Cancer Center, Omaha, Nebraska. [23] Wallace McCain Centre for Pancreatic Cancer, Department of Medical Oncology, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada. [24] Department of Pathology and Laboratory Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York. [25] Division of Medical Oncology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York. [26] Weill Cornell Medical College, New York, New York. [27] Department of Pathology, University Health Network, University of Toronto, Toronto, Ontario, Canada. [28] Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. [29] Department of Biomedical Informatics, Stony Brook University, Stony Brook, New York. [30] PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, Ontario, Canada. dtuveson@cshl.edu steven.gallinger@uhn.ca. [31] Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada. [32] Hepatobiliary/Pancreatic Surgical Oncology Program, University Health Network, Toronto, Ontario, Canada. [33] Cold Spring Harbor Laboratory, Cold Spring Harbor, New York. dtuveson@cshl.edu steven.gallinger@uhn.ca. [34]
DOI 10.1158/2159-8290.CD-18-0349
PMID 29853643
发布时间 2022-07-16
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