The Antibiotic-free pFAR4 Vector Paired with the Sleeping Beauty Transposon System Mediates Efficient Transgene Delivery in Human Cells.

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第一作者： Marie,Pastor

第一单位： CNRS, Unité de Technologies Chimiques et Biologiques pour la Santé (UTCBS), UMR 8258, 75006 Paris, France; Chimie ParisTech, PSL Research University, UTCBS, 75005 Paris, France; Université Paris Descartes, Sorbonne-Paris-Cité, UTCBS, 75006 Paris, France; INSERM, UTCBS U 1022, 75006 Paris, France.

作者： Marie,Pastor ^[1] ; Sandra,Johnen ^[2] ; Nina,Harmening ^[3] ; Mickäel,Quiviger ^[1] ; Julie,Pailloux ^[1] ; Martina,Kropp ^[3] ; Peter,Walter ^[2] ; Zoltán,Ivics ^[4] ; Zsuzsanna,Izsvák ^[5] ; Gabriele,Thumann ^[3] ; Daniel,Scherman ^[1] ; Corinne,Marie ^[6]

作者单位： CNRS, Unité de Technologies Chimiques et Biologiques pour la Santé (UTCBS), UMR 8258, 75006 Paris, France; Chimie ParisTech, PSL Research University, UTCBS, 75005 Paris, France; Université Paris Descartes, Sorbonne-Paris-Cité, UTCBS, 75006 Paris, France; INSERM, UTCBS U 1022, 75006 Paris, France. ^[1] Department of Ophthalmology, University Hospital RWTH Aachen, 52074 Aachen, Germany. ^[2] Experimental Ophthalmology, University of Geneva, 1205 Geneva, Switzerland; Department of Ophthalmology, University Hospitals of Geneva, 1205 Geneva, Switzerland. ^[3] Division of Medical Biotechnology, Paul Ehrlich Institute, 63225 Langen, Germany. ^[4] Max Delbrück Center for Molecular Medicine in the Helmholtz Association, 13092 Berlin, Germany. ^[5] CNRS, Unité de Technologies Chimiques et Biologiques pour la Santé (UTCBS), UMR 8258, 75006 Paris, France; Chimie ParisTech, PSL Research University, UTCBS, 75005 Paris, France; Université Paris Descartes, Sorbonne-Paris-Cité, UTCBS, 75006 Paris, France; INSERM, UTCBS U 1022, 75006 Paris, France. Electronic address: corinne.marie@parisdescartes.fr. ^[6]

关键词 PEDF RPE cells Sleeping Beauty transposon VEGF age-related macular degeneration antibiotic-free pFAR4 vector electroporation ocular gene therapy transfection

DOI 10.1016/j.omtn.2017.12.017

PMID 29858090

发布时间 2020-10-01

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