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首页> Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie> Curcumin regulates endogenous and exogenous metabolism via Nrf2-FXR-LXR pathway in NAFLD mice.

Curcumin regulates endogenous and exogenous metabolism via Nrf2-FXR-LXR pathway in NAFLD mice.

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作者： Caixia,Yan ^[1] ; Yirui,Zhang ^[1] ; Xiaoxu,Zhang ^[2] ; Jiye,Aa ^[1] ; Guangji,Wang ^[3] ; Yuan,Xie ^[4]

作者单位： Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China. ^[1] Jiangsu Key Laboratory of TCM Evaluation and Translational Research, Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing 211198, China. ^[2] Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China. Electronic address: gjwang@cpu.edu.cn. ^[3] Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China. Electronic address: yuanxie@cpu.edu.cn. ^[4]

关键词 CYP3A CYP7A Curcumin Endogenous metabolism Exogenous metabolism Metabolic regulation

主题词动物(Animals);姜黄素(Curcumin);细胞色素P450酶系统(Cytochrome P-450 Enzyme System);果糖(Fructose);肝细胞(Hepatocytes);脂类(Lipids);肝(Liver);男(雄)性(Male);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);NF-E2相关因子2(NF-E2-Related Factor 2);聚异戊烯磷酸盐类(Polyisoprenyl Phosphates);预防和防护用药(Protective Agents);受体, 胞质和核(Receptors, Cytoplasmic and Nuclear);信号传导(Signal Transduction);胆固醇调节元件结合蛋白质1(Sterol Regulatory Element Binding Protein 1)

DOI 10.1016/j.biopha.2018.05.135

PMID 29860219

发布时间 2018-12-02

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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

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