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首页> The Journal of biological chemistry> Heme and hemoglobin suppress amyloid β-mediated inflammatory activation of mouse astrocytes.

Heme and hemoglobin suppress amyloid β-mediated inflammatory activation of mouse astrocytes.

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作者： Sitara B,Sankar ^[1] ; Rebecca K,Donegan ^[2] ; Kajol J,Shah ^[1] ; Amit R,Reddi ^[3] ; Levi B,Wood ^[4]

作者单位： Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332. ^[1] School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332. ^[2] School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332; Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332. Electronic address: amit.reddi@chemistry.gatech.edu. ^[3] Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332; Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332; George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332. Electronic address: levi.wood@me.gatech.edu. ^[4]

关键词 Alzheimer disease amyloid-beta (AB)astrocyte heme hemoglobin

主题词阿尔茨海默病(Alzheimer Disease);淀粉样β肽类(Amyloid beta-Peptides);动物(Animals);星形细胞(Astrocytes);细胞, 培养的(Cells, Cultured);细胞因子类(Cytokines);血红素(Heme);血红蛋白类(Hemoglobins);免疫耐受(Immune Tolerance);炎症(Inflammation);小鼠(Mice);神经免疫调节(Neuroimmunomodulation);肽碎片(Peptide Fragments);吞噬作用(Phagocytosis)

DOI 10.1074/jbc.RA117.001050

PMID 29871926

发布时间 2021-03-17

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The Journal of biological chemistry

The Journal of biological chemistry

2018年293卷29期

11358-11373页

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