首页> Journal of medicinal chemistry> Integrated Strategy for Lead Optimization Based on Fragment Growing: The Diversity-Oriented-Target-Focused-Synthesis Approach.

Integrated Strategy for Lead Optimization Based on Fragment Growing: The Diversity-Oriented-Target-Focused-Synthesis Approach.

导出原文传递

翻译打印收藏纠错

第一作者： Laurent,Hoffer

第一单位： CRCM, CNRS, Inserm, Institut Paoli-Calmettes , Aix-Marseille University , 13009 Marseille , France.

作者： Laurent,Hoffer ^[1] ; Yuliia V,Voitovich ^[2] ; Brigitt,Raux ^[1] ; Kendall,Carrasco ^[1] ; Christophe,Muller ^[3] ; Aleksey Y,Fedorov ^[4] ; Carine,Derviaux ^[3] ; Agnès,Amouric ^[5] ; Stéphane,Betzi ^[1] ; Dragos,Horvath ^[6] ; Alexandre,Varnek ^[6] ; Yves,Collette ^[5] ; Sébastien,Combes ^[1] ; Philippe,Roche ^[1] ; Xavier,Morelli ^[5]

作者单位： CRCM, CNRS, Inserm, Institut Paoli-Calmettes , Aix-Marseille University , 13009 Marseille , France. ^[1] CRCM, CNRS, Inserm, Institut Paoli-Calmettes , Aix-Marseille University , 13009 Marseille , France.;Department of Organic Chemistry , Lobachevsky State University of Nizhni Novgorod , 23 Gagarin Avenue , 603950 Nizhni Novgorod , Russia. ^[2] IPC Drug Discovery Platform , Institut Paoli-Calmettes , 232 Boulevard de Sainte-Marguerite , 13009 Marseille , France. ^[3] Department of Organic Chemistry , Lobachevsky State University of Nizhni Novgorod , 23 Gagarin Avenue , 603950 Nizhni Novgorod , Russia. ^[4] CRCM, CNRS, Inserm, Institut Paoli-Calmettes , Aix-Marseille University , 13009 Marseille , France.;IPC Drug Discovery Platform , Institut Paoli-Calmettes , 232 Boulevard de Sainte-Marguerite , 13009 Marseille , France. ^[5] Laboratoire de Chemoinformatique, CNRS UMR7140 , 1 rue Blaise Pascal , 67000 Strasbourg , France. ^[6]

医学主题词药物发现(Drug Discovery);结果可重复性(Reproducibility of Results);小分子化合物库(Small Molecule Libraries);时间因素(Time Factors)

DOI 10.1021/acs.jmedchem.8b00653

PMID 29883107

发布时间 2019-06-07

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交