Modifier locus mapping of a transgenic F2 mouse population identifies CCDC115 as a novel aggressive prostate cancer modifier gene in humans.

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第一作者： Jean M,Winter

第一单位： Metastasis Genetics Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, NIH, Bethesda, MD, 20892, USA.;Present address: Dame Roma Mitchell Cancer Research Laboratories, Adelaide Health and Medical Sciences, The University of Adelaide, Adelaide, South Australia, 5000, Australia.

作者： Jean M,Winter ^[1] ; Natasha L,Curry ^[2] ; Derek M,Gildea ^[3] ; Kendra A,Williams ^[2] ; Minnkyong,Lee ^[2] ; Ying,Hu ^[4] ; Nigel P S,Crawford ^[5]

作者单位： Metastasis Genetics Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, NIH, Bethesda, MD, 20892, USA.;Present address: Dame Roma Mitchell Cancer Research Laboratories, Adelaide Health and Medical Sciences, The University of Adelaide, Adelaide, South Australia, 5000, Australia. ^[1] Metastasis Genetics Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, NIH, Bethesda, MD, 20892, USA. ^[2] Computational and Statistical Genomics Branch, National Human Genome Research Institute, NIH, Bethesda, MD, 20892, USA. ^[3] Center for Biomedical Informatics and Information Technology, National Cancer Institute, NIH, Rockville, MD, 20892, USA. ^[4] Metastasis Genetics Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, NIH, Bethesda, MD, 20892, USA. nigel.crawford@sanofi.com.;, Present address: Sanofi, 55 Corporate Dr., Bridgewater, NJ, 08897, USA. nigel.crawford@sanofi.com. ^[5]

关键词 CCDC115 DNAJC10 Germline variation LNCaP Prostate cancer Quantitative trait loci RNF149 STYXL1 TRAMP mouse model