Metformin Improves Neurologic Outcome Via AMP-Activated Protein Kinase-Mediated Autophagy Activation in a Rat Model of Cardiac Arrest and Resuscitation.

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作者： Juan,Zhu ^[1] ; Kewei,Liu ^[1] ; Kaibin,Huang ^[1] ; Yong,Gu ^[1] ; Yafang,Hu ^[1] ; Suyue,Pan ^[2] ; Zhong,Ji ^[2]

作者单位： Department of Neurology, Nanfang Hospital Southern Medical University, Guangdong, China. ^[1] Department of Neurology, Nanfang Hospital Southern Medical University, Guangdong, China jizhong@fimmu.com pansuyue82@126.com. ^[2]

关键词 AMP‐activated protein kinase signal transduction autophagy cardiac arrest diabetic therapy/glitazones metformin neuroprotection

主题词 AMP活化蛋白激酶类(AMP-Activated Protein Kinases);动物(Animals);细胞凋亡(Apoptosis);自噬(Autophagy);脑缺血(Brain Ischemia);CA1区, 海马(CA1 Region, Hippocampal);心肺复苏术(Cardiopulmonary Resuscitation);疾病模型, 动物(Disease Models, Animal);心脏停搏(Heart Arrest);男(雄)性(Male);二甲双胍(Metformin);神经元(Neurons);神经保护药(Neuroprotective Agents);磷酰化(Phosphorylation);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);信号传导(Signal Transduction)

DOI 10.1161/JAHA.117.008389

PMID 29895585

发布时间 2024-07-15

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Journal of the American Heart Association

2018年7卷12期

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Metformin Improves Neurologic Outcome Via AMP-Activated Protein Kinase-Mediated Autophagy Activation in a Rat Model of Cardiac Arrest and Resuscitation.

Journal of the American Heart Association

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Journal of the American Heart Association

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Metformin Improves Neurologic Outcome Via AMP-Activated Protein Kinase-Mediated Autophagy Activation in a Rat Model of Cardiac Arrest and Resuscitation.

Journal of the American Heart Association

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Journal of the American Heart Association

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