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UCHL3 Regulates Topoisomerase-Induced Chromosomal Break Repair by Controlling TDP1 Proteostasis.

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第一作者： Chunyan,Liao

第一单位： Krebs Institute, Department of Molecular Biology and Biotechnology, Firth Court, University of Sheffield, S10 2TN Sheffield, UK.

作者： Chunyan,Liao ^[1] ; Ryan,Beveridge ^[1] ; Jessica J R,Hudson ^[2] ; Jacob D,Parker ^[1] ; Shih-Chieh,Chiang ^[1] ; Swagat,Ray ^[1] ; Mohamed E,Ashour ^[3] ; Ian,Sudbery ^[1] ; Mark J,Dickman ^[4] ; Sherif F,El-Khamisy ^[5]

作者单位： Krebs Institute, Department of Molecular Biology and Biotechnology, Firth Court, University of Sheffield, S10 2TN Sheffield, UK. ^[1] Krebs Institute, Department of Molecular Biology and Biotechnology, Firth Court, University of Sheffield, S10 2TN Sheffield, UK; Genome Damage and Stability Centre, University of Sussex, Brighton, UK. ^[2] Center for Genomics, Helmy Institute, Zewail City of Science and Technology, Giza, Egypt. ^[3] Department of Chemical and Biological Engineering, University of Sheffield, Sheffield, UK. ^[4] Krebs Institute, Department of Molecular Biology and Biotechnology, Firth Court, University of Sheffield, S10 2TN Sheffield, UK; Center for Genomics, Helmy Institute, Zewail City of Science and Technology, Giza, Egypt. Electronic address: s.el-khamisy@sheffield.ac.uk. ^[5]

关键词 SCAN1 TDP UCHL3 aging cancer heart failure myocardial infarction neurodegeneration rhabdosarcoma topoisomerase