Heterodimeric Fc-fused IL12 shows potent antitumor activity by generating memory CD8<sup>+</sup> T cells.

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作者： Keunok,Jung ^[1] ; Ji-Hee,Ha ^[2] ; Jung-Eun,Kim ^[2] ; Jeong-Ah,Kim ^[2] ; Ye-Jin,Kim ^[2] ; Chul-Ho,Kim ^[2] ; Yong-Sung,Kim ^[3]

作者单位： Priority Research Center for Molecular Science & Technology, Ajou University, Suwon, Republic of Korea. ^[1] Department of Molecular Science and Technology, Ajou University, Suwon, Republic of Korea. ^[2] Department of Otolaryngology, Ajou University School of Medicine, Suwon, Republic of Korea. ^[3]

关键词 Immunoglobulin heterodimeric Fc Inflammation and cancer Interleukin 12 Models of immunostimulation Therapeutic antibodies anti-tumor therapy large established immunogenic tumors memory CD8+ T cells monovalent binding format

DOI 10.1080/2162402X.2018.1438800

PMID 29900039

发布时间 2022-03-30

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Oncoimmunology

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Heterodimeric Fc-fused IL12 shows potent antitumor activity by generating memory CD8<sup>+</sup> T cells.

Oncoimmunology

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Oncoimmunology

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Heterodimeric Fc-fused IL12 shows potent antitumor activity by generating memory CD8<sup>+</sup> T cells.

Oncoimmunology

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Oncoimmunology

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