Loss of Trem2 in microglia leads to widespread disruption of cell coexpression networks in mouse brain.

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第一作者： Guillermo,Carbajosa

第一单位： Department of Biostatistics and Health Informatics, Institute of Psychiatry Psychology and Neuroscience, King's College London, London, UK. Electronic address: guillermo.carbajosa_antona@kcl.ac.uk.

作者： Guillermo,Carbajosa ^[1] ; Karim,Malki ^[2] ; Nathan,Lawless ^[2] ; Hong,Wang ^[3] ; John W,Ryder ^[3] ; Eva,Wozniak ^[4] ; Kristie,Wood ^[4] ; Charles A,Mein ^[4] ; Richard J B,Dobson ^[5] ; David A,Collier ^[2] ; Michael J,O'Neill ^[2] ; Angela K,Hodges ^[6] ; Stephen J,Newhouse ^[5]

作者单位： Department of Biostatistics and Health Informatics, Institute of Psychiatry Psychology and Neuroscience, King's College London, London, UK. Electronic address: guillermo.carbajosa_antona@kcl.ac.uk. ^[1] Eli Lilly and Company, Windlesham, UK. ^[2] Eli Lilly and Company, Indianapolis, IN, USA. ^[3] Barts and the London Genome Centre, John Vane Science Centre, Barts and the London School of Medicine and Dentistry, London, UK. ^[4] Department of Biostatistics and Health Informatics, Institute of Psychiatry Psychology and Neuroscience, King's College London, London, UK; NIHR Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London, London, UK; Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, London, UK. ^[5] Maurice Wohl Clinical Neuroscience Institute James Black Centre Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK. ^[6]

关键词 Alzheimer's disease Endothelial cells Knockout mouse model RNA-Seq TREM2 Weighted gene coexpression network analysis