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首页> Bioscience reports> Simultaneous activation of innate and adaptive immunity participates in the development of renal injury in a model of heavy proteinuria.

Simultaneous activation of innate and adaptive immunity participates in the development of renal injury in a model of heavy proteinuria.

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作者： Viviane Dias,Faustino ^[1] ; Simone Costa Alarcon,Arias ^[2] ; Victor,Ferreira Ávila ^[2] ; Orestes,Foresto-Neto ^[2] ; Fernanda Florencia Fregnan,Zambom ^[2] ; Flavia Gomes,Machado ^[2] ; Luciene,Machado Dos Reis ^[2] ; Denise Maria Avancini Costa,Malheiros ^[2] ; Rildo Aparecido,Volpini ^[2] ; Niels Olsen Saraiva,Camara ^[2] ; Roberto,Zatz ^[3] ; Clarice Kazue,Fujihara ^[1]

作者单位： Renal Division, Department of Clinical Medicine, Faculty of Medicine, University of São Paulo, São Paulo, Brazil roberto.zatz@gmail.com vianedias@hotmail.com. ^[1] Renal Division, Department of Clinical Medicine, Faculty of Medicine, University of São Paulo, São Paulo, Brazil. ^[2] Laboratory of Transplantation Immunobiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil. ^[3]

关键词 NF-κB system NLRP3 inflammasome adaptive immunity chronic kidney disease proteinuria

主题词急性肾损伤(Acute Kidney Injury);适应性免疫(Adaptive Immunity);动物(Animals);疾病模型, 动物(Disease Models, Animal);酶抑制剂(Enzyme Inhibitors);纤维化(Fibrosis);免疫, 先天(Immunity, Innate);肾(Kidney);男(雄)性(Male);霉酚酸(Mycophenolic Acid);NF-κB(NF-kappa B);蛋白尿(Proteinuria);大鼠, Wistar(Rats, Wistar)

DOI 10.1042/BSR20180762

PMID 29914975

发布时间 2019-04-19

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