换一批
换一批NUDT15 codon 139 is the best pharmacogenetic marker for predicting thiopurine-induced severe adverse events in Japanese patients with inflammatory bowel disease: a multicenter study.
作者：
Yoichi,Kakuta [1]
;
Yosuke,Kawai [2]
;
Daisuke,Okamoto [3]
;
Tetsuya,Takagawa [4]
;
Kentaro,Ikeya [5]
;
Hirotake,Sakuraba [6]
;
Atsushi,Nishida [7]
;
Shoko,Nakagawa [8]
;
Miki,Miura [9]
;
Takahiko,Toyonaga [10]
;
Kei,Onodera [11]
;
Masaru,Shinozaki [12]
;
Yoh,Ishiguro [13]
;
Shinta,Mizuno [14]
;
Masahiro,Takahara [15]
;
Shunichi,Yanai [16]
;
Ryota,Hokari [17]
;
Tomoo,Nakagawa [18]
;
Hiroshi,Araki [19]
;
Satoshi,Motoya [20]
;
Takeo,Naito [21]
;
Rintaro,Moroi [4]
;
Hisashi,Shiga [4]
;
Katsuya,Endo [4]
;
Taku,Kobayashi [4]
;
Makoto,Naganuma [11]
;
Sakiko,Hiraoka [15]
;
Takayuki,Matsumoto [16]
;
Shiro,Nakamura [17]
;
Hiroshi,Nakase [5]
;
Tadakazu,Hisamatsu [12]
;
Makoto,Sasaki [10]
;
Hiroyuki,Hanai [9]
;
Akira,Andoh [6]
;
Masao,Nagasaki [8]
;
Yoshitaka,Kinouchi [2]
;
Tooru,Shimosegawa [22]
;
Atsushi,Masamune [4]
;
Yasuo,Suzuki [4]
;
MENDEL study group [23]
作者单位：
Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo, Aoba, Sendai, 980-8574, Japan. ykakuta@med.tohoku.ac.jp.
[1]
Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
[2]
Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
[3]
Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo, Aoba, Sendai, 980-8574, Japan.
[4]
Division of Internal Medicine, Department of Inflammatory Bowel Disease, Hyogo College of Medicine, Nishinomiya, Japan.
[5]
Centre for Gastroenterology and Inflammatory Bowel Disease Research, Hamamatsu South Hospital, Hamamatsu, Japan.
[6]
Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
[7]
Department of Gastroenterology, Shiga University of Medical Science, Otsu, Japan.
[8]
Division of Gastroenterology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute, Japan.
[9]
The Third Department of Internal Medicine, Kyorin University School of Medicine, Mitaka, Japan.
[10]
Center for Advanced IBD Research and Treatment, Kitasato University Kitasato Institute Hospital, Tokyo, Japan.
[11]
Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo, Japan.
[12]
Department of Surgery, IMSUT Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
[13]
Department of Gastroenterology and Hematology, Hirosaki National Hospital, Hirosaki, Japan.
[14]
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
[15]
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
[16]
Division of Gastroenterology, Department of Internal Medicine, School of Medicine, Iwate Medical University, Morioka, Japan.
[17]
Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Defense Medical College, Tokorozawa, Japan.
[18]
Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan.
[19]
Division of Endscopy, Gifu University Hospital, Gifu, Japan.
[20]
IBD Center, Sapporo-Kosei General Hospital, Sapporo, Japan.
[21]
Health Administration Center, Center for the Advancement of Higher Education, Tohoku University, Sendai, Japan.
[22]
Department of Internal Medicine, Toho University Sakura Medical Center, Sakura, Japan.
[23]
主题词
秃发(Alopecia);抗体, 单克隆(Antibodies, Monoclonal);硫唑嘌呤(Azathioprine);生物学标记, 药理学(Biomarkers, Pharmacological);疾病遗传易感性(Genetic Predisposition to Disease);全基因组关联研究(Genome-Wide Association Study);染色体结构变异(Genomic Structural Variation);单倍型(Haplotypes);人类(Humans);免疫抑制剂(Immunosuppressive Agents);炎性肠疾病(Inflammatory Bowel Diseases);日本(Japan);白细胞减少(Leukopenia);Logistic模型(Logistic Models);氨水杨酸(Mesalamine);遗传药理学(Pharmacogenetics);焦磷酸酶类(Pyrophosphatases);ROC曲线(ROC Curve);回顾性研究(Retrospective Studies);危险(Risk);柳氮磺胺吡啶(Sulfasalazine)
DOI
10.1007/s00535-018-1486-7
PMID
29923122
发布时间
2021-02-12
- 浏览17
Journal of gastroenterology
Journal of gastroenterology
1065-1078页
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