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Cilia-localized LKB1 regulates chemokine signaling, macrophage recruitment, and tissue homeostasis in the kidney.

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作者单位: Renal Department, University Medical Center, Freiburg, Germany. [1] Faculty of Medicine, University of Freiburg, Freiburg, Germany. [2] INSERM U1151, Institut Necker Enfants Malades, Department of Growth and Signaling, Université Paris Descartes-Sorbonne Paris Cité, Paris, France. [3] Service d'Explorations Fonctionnelles, Hôpital Necker-Enfants Malades, Paris, France. [4] Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg, Germany. [5] Department of Neuroanatomy, Albert-Ludwigs-University Freiburg, Freiburg, Germany. [6] III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. [7] Medical Physics, Department of Radiology, and Comprehensive Cancer Center, University Medical Center, Freiburg, Germany. [8] German Cancer Consortium (DKTK), Freiburg, Germany. [9] German Cancer Research Center (DKFZ), Heidelberg, Germany. [10] Department of Hematology, Oncology and Stem Cell Transplantation, University Medical Center, Freiburg, Germany. [11] Center for Biological Systems Analysis (ZBSA), Core Facility Proteomics, Albert-Ludwigs-University Freiburg, Freiburg, Germany. [12] INSERM UMR1163, Laboratory of Inherited Kidney Diseases, Necker-Enfants Malades Hospital, Paris, France. [13] Imagine Institute, Université Paris Descartes-Sorbonne Paris Cité, Paris, France. [14] Center for Biological Systems Analysis (ZBSA), Life Imaging Center, Albert-Ludwigs-University Freiburg, Freiburg, Germany. [15] Center for Biological Signaling Studies (BIOSS), Albert-Ludwigs-University Freiburg, Freiburg, Germany. [16] Center for Biological Systems Analysis (ZBSA), Albert-Ludwigs-University Freiburg, Freiburg, Germany. [17] Department of Biology, University of Fribourg, Fribourg, Switzerland. [18] Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany. [19] Systems Biology of the Cellular Microenvironment Group, Institute of Molecular Medicine and Cell Research (IMMZ), Albert-Ludwigs-University, Freiburg, Germany. [20] Department of Rheumatology and Clinical Immunology, Charité - University Medical Centre Berlin, Berlin, Germany. [21] Renal Department, University Medical Center, Freiburg, Germany wolfgang.kuehn@uniklinik-freiburg.de. [22]
DOI 10.15252/embj.201798615
PMID 29925518
发布时间 2022-01-29
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