Immune cell contexture in the bone marrow tumor microenvironment impacts therapy response in CML.-论文-万方医学网

作者： Oscar,Brück ^[1] ; Sami,Blom ^[2] ; Olli,Dufva ^[1] ; Riku,Turkki ^[2] ; Himanshu,Chheda ^[2] ; Antonio,Ribeiro ^[2] ; Panu,Kovanen ^[3] ; Tero,Aittokallio ^[2] ; Perttu,Koskenvesa ^[4] ; Olli,Kallioniemi ^[1] ; Kimmo,Porkka ^[2] ; Teijo,Pellinen ^[5] ; Satu,Mustjoki ^[1]

作者单位： Hematology Research Unit Helsinki, University of Helsinki and Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland. ^[1] Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland. ^[2] Department of Pathology, University of Helsinki and HUSLAB, Helsinki University Hospital, Helsinki, Finland. ^[3] Department of Mathematics and Statistics, University of Turku, Turku, Finland. ^[4] Science for Life Laboratory, Karolinska Institutet, Department of Oncology and Pathology, Solna, Sweden. ^[5] Hematology Research Unit Helsinki, University of Helsinki and Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland. satu.mustjoki@helsinki.fi. ^[6] Department of Clinical Chemistry, University of Helsinki, Helsinki, Finland. satu.mustjoki@helsinki.fi. ^[7]

主题词成年人(Adult);老年人(Aged);老年人, 80以上(Aged, 80 and over);活组织检查(Biopsy);骨髓(Bone Marrow);女(雌)性(Female);流式细胞术(Flow Cytometry);组织相容性抗原Ⅰ类(Histocompatibility Antigens Class I);人类(Humans);免疫组织化学(Immunohistochemistry);免疫调节(Immunomodulation);白血病, 髓系, 慢性, BCR-ABL阳性(Leukemia, Myelogenous, Chronic, BCR-ABL Positive);白细胞计数(Leukocyte Count);淋巴细胞计数(Lymphocyte Count);男(雄)性(Male);中年人(Middle Aged);蛋白激酶抑制剂(Protein Kinase Inhibitors);T淋巴细胞亚群(T-Lymphocyte Subsets);T淋巴细胞(T-Lymphocytes);组织阵列分析(Tissue Array Analysis);治疗结果(Treatment Outcome);肿瘤微环境(Tumor Microenvironment);青年人(Young Adult)

DOI 10.1038/s41375-018-0175-0

PMID 29925907

发布时间 2021-01-05

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Immune cell contexture in the bone marrow tumor microenvironment impacts therapy response in CML.

Leukemia

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Leukemia

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Immune cell contexture in the bone marrow tumor microenvironment impacts therapy response in CML.

Leukemia

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Leukemia

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