The MELAS mutation m.3243A>G promotes reactivation of fetal cardiac genes and an epithelial-mesenchymal transition-like program via dysregulation of miRNAs.-论文-万方医学网

第一作者： Salvador,Meseguer

第一单位： RNA Modification and Mitochondrial Diseases Laboratory, Centro de Investigación Príncipe Felipe (CIPF), Carrer d'Eduardo Primo Yúfera 3, Valencia 46012, Spain. Electronic address: smeseguer@cipf.es.

作者： Salvador,Meseguer ^[1] ; Joaquin,Panadero ^[2] ; Carmen,Navarro-González ^[3] ; Magda,Villarroya ^[4] ; Rachid,Boutoual ^[5] ; Giacomo Pietro,Comi ^[6] ; M-Eugenia,Armengod ^[7]

作者单位： RNA Modification and Mitochondrial Diseases Laboratory, Centro de Investigación Príncipe Felipe (CIPF), Carrer d'Eduardo Primo Yúfera 3, Valencia 46012, Spain. Electronic address: smeseguer@cipf.es. ^[1] Unidad de Genómica, Instituto de Investigación Sanitaria La Fe, Avenida Fernando Abril Martorell, 106 Torre A 7ª planta, Valencia 46026, Spain. Electronic address: joaquin_panadero@iislafe.es. ^[2] RNA Modification and Mitochondrial Diseases Laboratory, Centro de Investigación Príncipe Felipe (CIPF), Carrer d'Eduardo Primo Yúfera 3, Valencia 46012, Spain. Electronic address: cnavarrog@cipf.es. ^[3] RNA Modification and Mitochondrial Diseases Laboratory, Centro de Investigación Príncipe Felipe (CIPF), Carrer d'Eduardo Primo Yúfera 3, Valencia 46012, Spain. Electronic address: mvillarroya@cipf.es. ^[4] RNA Modification and Mitochondrial Diseases Laboratory, Centro de Investigación Príncipe Felipe (CIPF), Carrer d'Eduardo Primo Yúfera 3, Valencia 46012, Spain. Electronic address: rboutoual@cipf.es. ^[5] Dino Ferrari Centre, Department of Pathophysiology and Transplantation (DEPT), University of Milan, I.R.C.C.S. Foundation Ca' Granda, Ospedale Maggiore Policlinico, via F. Sforza 35, 20122 Milan, Italy. Electronic address: giacomo.comi@unimi.it. ^[6] RNA Modification and Mitochondrial Diseases Laboratory, Centro de Investigación Príncipe Felipe (CIPF), Carrer d'Eduardo Primo Yúfera 3, Valencia 46012, Spain; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) node 721, Madrid 28029, Spain. Electronic address: marmengod@cipf.es. ^[7]

主题词细胞系, 肿瘤(Cell Line, Tumor);DNA, 线粒体(DNA, Mitochondrial);减量调节(Down-Regulation);上皮-间质转化(Epithelial-Mesenchymal Transition);基因表达调控, 发育期(Gene Expression Regulation, Developmental);心脏(Heart);心力衰竭(Heart Failure);高通量核苷酸序列分析(High-Throughput Nucleotide Sequencing);人类(Humans);MELAS综合征(MELAS Syndrome);微RNAs(MicroRNAs);线粒体(Mitochondria);肌, 骨骼(Muscle, Skeletal);突变(Mutation);心肌(Myocardium);氧化磷酸化(Oxidative Phosphorylation);RNA, 转移, 亮氨酸(RNA, Transfer, Leu);序列分析, RNA(Sequence Analysis, RNA);信号传导(Signal Transduction);TGFβ超家族蛋白质类(TGF-beta Superfamily Proteins);增量调节(Up-Regulation)

DOI 10.1016/j.bbadis.2018.06.014

PMID 29928977

发布时间 2018-12-11

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The MELAS mutation m.3243A>G promotes reactivation of fetal cardiac genes and an epithelial-mesenchymal transition-like program via dysregulation of miRNAs.

Biochimica et biophysica acta. Molecular basis of disease

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Biochimica et biophysica acta. Molecular basis of disease

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The MELAS mutation m.3243A&gt;G promotes reactivation of fetal cardiac genes and an epithelial-mesenchymal transition-like program via dysregulation of miRNAs.

Biochimica et biophysica acta. Molecular basis of disease

相似文献

Biochimica et biophysica acta. Molecular basis of disease

相关期刊

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The MELAS mutation m.3243A>G promotes reactivation of fetal cardiac genes and an epithelial-mesenchymal transition-like program via dysregulation of miRNAs.