siRNA Library Screening Identifies a Druggable Immune-Signature Driving Esophageal Adenocarcinoma Cell Growth.

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作者： Shane P,Duggan ^[1] ; Catherine,Garry ^[2] ; Fiona M,Behan ^[3] ; Sinead,Phipps ^[4] ; Hiromi,Kudo ^[4] ; Murat,Kirca ^[4] ; Abdul,Zaheer ^[5] ; Sarah,McGarrigle ^[4] ; John V,Reynolds ^[6] ; Robert,Goldin ^[6] ; Steve E,Kalloger ^[7] ; David F,Schaeffer ^[7] ; Aideen,Long ^[5] ; Jessica,Strid ^[8] ; Dermot,Kelleher ^[8]

作者单位： Department of Medicine, Division of Gastroenterology, University of British Columbia, Vancouver, British Columbia, Canada. ^[1] Life Science Institute, University of British Columbia, Vancouver, British Columbia, Canada. ^[2] Centre for Complement and Inflammation Research, Imperial College London, London, United Kingdom. ^[3] Department of Clinical Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland. ^[4] Centre for Pathology, St Mary's Hospital, Imperial College London, London, United Kingdom. ^[5] Department of Gastroenterology, St James' Hospital, Dublin, Ireland. ^[6] Department of Surgery, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland. ^[7] Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada. ^[8]

关键词 ATCC, American Type Culture Collection BE, Barrett’s esophagus Barrett’s Esophagus EAC, esophageal adenocarcinoma ERBB2, erb-b2 receptor tyrosine kinase 2 ESCC, esophageal squamous cell carcinoma Esophageal Adenocarcinoma FCS, fetal calf serum GEM, gene expression microarray GERD, gastroesophageal reflux disease GO, gene ontology HGD, high-grade dysplastic IL, interleukin Inflammation JAK-STAT, Janus kinase/signal transducer-and-activator of transcription LIF, leukemia inhibitory factor MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide PBS, phosphate-buffered saline RA, rheumatoid arthritis SV, somatic variation SYK, spleen tyrosine kinase TCGA, The Cancer Genome Atlas TREM2, triggering receptor expressed on myeloid cells 2 Therapeutic Targets VEGFA, vascular endothelial growth factor A mRNA, messenger RNA siRNA, small interfering RNA

DOI 10.1016/j.jcmgh.2018.01.012

PMID 29930979

发布时间 2022-03-21

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Cellular and molecular gastroenterology and hepatology

2018年5卷4期

569-590页

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siRNA Library Screening Identifies a Druggable Immune-Signature Driving Esophageal Adenocarcinoma Cell Growth.

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siRNA Library Screening Identifies a Druggable Immune-Signature Driving Esophageal Adenocarcinoma Cell Growth.

Cellular and molecular gastroenterology and hepatology

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Cellular and molecular gastroenterology and hepatology

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