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Euphol, a tetracyclic triterpene, from Euphorbia tirucalli induces autophagy and sensitizes temozolomide cytotoxicity on glioblastoma cells.

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第一作者： Viviane A O,Silva

第一单位： Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, 14784 400, Brazil.

作者： Viviane A O,Silva ^[1] ; Marcela N,Rosa ^[1] ; Vera,Miranda-Gonçalves ^[2] ; Angela M,Costa ^[2] ; Aline,Tansini ^[1] ; Adriane F,Evangelista ^[1] ; Olga,Martinho ^[3] ; Adriana C,Carloni ^[1] ; Chris,Jones ^[4] ; João Paulo,Lima ^[5] ; Luiz F,Pianowski ^[6] ; Rui Manuel,Reis ^[7]

作者单位： Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, 14784 400, Brazil. ^[1] Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, 4710-057, Braga, Portugal.;ICVS/3B's - PT Government Associate Laboratory, 4806-909, Braga, Guimarães, Portugal. ^[2] Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, 14784 400, Brazil.;Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, 4710-057, Braga, Portugal.;ICVS/3B's - PT Government Associate Laboratory, 4806-909, Braga, Guimarães, Portugal. ^[3] Division of Molecular Pathology, The Institute of Cancer Research, London, UK.;Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK. ^[4] Medical Oncology Department, AC Camargo Cancer Center, São Paulo, 01509-010, Brazil. ^[5] Kyolab laboratório de pesquisa Farmacêutica Ltda, Valinhos, São Paulo, 13273-105, Brazil. ^[6] Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, 14784 400, Brazil. ruireis.hcb@gmail.com.;Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, 4710-057, Braga, Portugal. ruireis.hcb@gmail.com.;ICVS/3B's - PT Government Associate Laboratory, 4806-909, Braga, Guimarães, Portugal. ruireis.hcb@gmail.com. ^[7]

关键词 Anticancer Cytotoxic activity and euphol Glioblastoma