Defective Dendritic Cell Cytotoxic Activity of High-Grade Glioma Patients' Results from the Low Expression of Membrane TNFα and Can Be Corrected In Vitro by Treatment with Recombinant IL-2 or Exogenic Double-Stranded DNA.

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第一作者： Tamara,Tyrinova

第一单位： 1 Laboratory of Cellular Immunotherapy, Institute of Fundamental and Clinical Immunology , Novosibirsk, Russia .

作者： Tamara,Tyrinova ^[1] ; Olga,Leplina ^[1] ; Sergey,Mishinov ^[2] ; Marina,Tikhonova ^[1] ; Anton,Kalinovskiy ^[3] ; Sergey,Chernov ^[3] ; Evgeniya,Dolgova ^[4] ; Vyacheslav,Stupak ^[2] ; Evgeniya,Voronina ^[5] ; Sergey,Bogachev ^[4] ; Ekaterina,Shevela ^[1] ; Alexander,Ostanin ^[1] ; Elena,Chernykh ^[1]

作者单位： 1 Laboratory of Cellular Immunotherapy, Institute of Fundamental and Clinical Immunology , Novosibirsk, Russia . ^[1] 2 Department of Neurosurgery, Novosibirsk Research Institute of Traumatology and Orthopedics named after Ya.L. Zivian , Novosibirsk, Russia . ^[2] 3 Department of Neurosurgery, Federal Neurosurgical Center , Novosibirsk, Russia . ^[3] 4 Laboratory of Induced Cellular Processes, The Federal Research Center Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences , Novosibirsk, Russia . ^[4] 5 Laboratory of Morphological and Molecular Biology Techniques, Regional Center of High Medical Technologies , Novosibirsk, Russia . ^[5]

关键词 TNFα TNFα-converting enzyme dendritic cells glioma interferon alpha interleukin-2