Autophagy Regulates the Liver Clock and Glucose Metabolism by Degrading CRY1.

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第一作者： Miriam,Toledo

第一单位： Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

作者： Miriam,Toledo ^[1] ; Ana,Batista-Gonzalez ^[1] ; Emilio,Merheb ^[2] ; Marie Louise,Aoun ^[3] ; Elena,Tarabra ^[3] ; Daorong,Feng ^[3] ; Jaakko,Sarparanta ^[1] ; Paola,Merlo ^[4] ; Francesco,Botrè ^[5] ; Gary J,Schwartz ^[6] ; Jeffrey E,Pessin ^[7] ; Rajat,Singh ^[8]

作者单位： Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. ^[1] Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA. ^[2] Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA. ^[3] Laboratorio Antidoping, Federazione Medico Sportiva Italiana, Largo Giulio Onesti 1, Rome, RM 00197, Italy. ^[4] Laboratorio Antidoping, Federazione Medico Sportiva Italiana, Largo Giulio Onesti 1, Rome, RM 00197, Italy; Department of Experimental Medicine, "Sapienza" University of Rome, Viale Regina Elena 324, Rome, RM 00161, Italy. ^[5] Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Neurology and Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Diabetes Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA. ^[6] Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Diabetes Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA. ^[7] Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Diabetes Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: rajat.singh@einstein.yu.edu. ^[8]

关键词 CRY1 FoxO1 LC3 autophagy circadian clock gluconeogenesis glucose metabolism liver lysosome obesity