A pharmacodynamic study of sirolimus and metformin in patients with advanced solid tumors.

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第一作者： Amikar,Sehdev

第一单位： Section of Hematology Oncology, Department of Medicine, University of Chicago, 5841 S. Maryland Avenue, MC 2115, Chicago, IL, 60637, USA. asehdev@iupui.edu.

作者： Amikar,Sehdev ^[1] ; Theodore,Karrison ^[2] ; Yuanyuan,Zha ^[3] ; Linda,Janisch ^[4] ; Michelle,Turcich ^[4] ; Ezra E W,Cohen ^[4] ; Michael,Maitland ^[4] ; Blase N,Polite ^[4] ; Thomas F,Gajewski ^[4] ; Ravi,Salgia ^[4] ; Navin,Pinto ^[4] ; Marc B,Bissonnette ^[4] ; Gini F,Fleming ^[5] ; Mark J,Ratain ^[4] ; Manish R,Sharma ^[4]

作者单位： Section of Hematology Oncology, Department of Medicine, University of Chicago, 5841 S. Maryland Avenue, MC 2115, Chicago, IL, 60637, USA. asehdev@iupui.edu. ^[1] Division of Hematology Oncology, Department of Medicine, Indiana University, 535 Barnhill Dr., RT 130B, Indianapolis, IN, 46202, USA. asehdev@iupui.edu. ^[2] Department of Public Health Sciences, University of Chicago, Chicago, IL, USA. ^[3] Section of Hematology Oncology, Department of Medicine, University of Chicago, 5841 S. Maryland Avenue, MC 2115, Chicago, IL, 60637, USA. ^[4] Section of Gastroenterology, Department of Medicine, University of Chicago, Chicago, IL, USA. ^[5] Section of Hematology Oncology, Department of Medicine, University of Chicago, 5841 S. Maryland Avenue, MC 2115, Chicago, IL, 60637, USA. msharma@bsd.uchicago.edu. ^[6]

关键词 Metformin P70S6K and mTOR Pharmacodynamics Sirolimus Solid tumors