Loss of <i>Dis3l2</i> partially phenocopies Perlman syndrome in mice and results in up-regulation of <i>Igf2</i> in nephron progenitor cells.

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作者： Ryan W,Hunter ^[1] ; Yangjian,Liu ^[2] ; Hema,Manjunath ^[1] ; Asha,Acharya ^[1] ; Benjamin T,Jones ^[1] ; He,Zhang ^[1] ; Beibei,Chen ^[3] ; Harini,Ramalingam ^[4] ; Robert E,Hammer ^[3] ; Yang,Xie ^[4] ; James A,Richardson ^[1] ; Dinesh,Rakheja ^[5] ; Thomas J,Carroll ^[3] ; Joshua T,Mendell ^[4]

作者单位： Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. ^[1] Medical Scientist Training Program, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. ^[2] Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. ^[3] Quantitative Biomedical Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. ^[4] Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. ^[5] Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. ^[6] Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. ^[7] Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. ^[8] Division of Pathology and Laboratory Medicine, Children's Health, Dallas, Texas 75235, USA. ^[9] Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. ^[10] Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. ^[11] Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. ^[12]

关键词 DIS3L2 Igf2 LIN28 Perlman syndrome Wilms tumor let-7 microRNA