第一单位：
Human Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.;Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA.;Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.;Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
作者：
Andrew M,Intlekofer [1]
;
Alan H,Shih [2]
;
Bo,Wang [3]
;
Abbas,Nazir [4]
;
Ariën S,Rustenburg [5]
;
Steven K,Albanese [6]
;
Minal,Patel [7]
;
Christopher,Famulare [7]
;
Fabian M,Correa [4]
;
Naofumi,Takemoto [4]
;
Vidushi,Durani [4]
;
Hui,Liu [8]
;
Justin,Taylor [2]
;
Noushin,Farnoud [9]
;
Elli,Papaemmanuil [9]
;
Justin R,Cross [8]
;
Martin S,Tallman [10]
;
Maria E,Arcila [11]
;
Mikhail,Roshal [11]
;
Gregory A,Petsko [12]
;
Bin,Wu [13]
;
Sung,Choe [13]
;
Zenon D,Konteatis [13]
;
Scott A,Biller [13]
;
John D,Chodera [5]
;
Craig B,Thompson [14]
;
Ross L,Levine [15]
;
Eytan M,Stein [16]
作者单位：
Human Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.;Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA.;Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.;Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
[1]
Human Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.;Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA.;Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.;Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
[2]
Human Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.;Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA.;Cancer Biology & Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
[3]
Human Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.;Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
[4]
Computational & Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
[5]
Computational & Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.;Gerstner Sloan Kettering Graduate School, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
[6]
Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
[7]
The Donald B. and Catherine C. Marron Cancer Metabolism Center, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
[8]
Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA.;Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.;Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
[9]
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.;Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
[10]
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
[11]
Feil Family Brain and Mind Research Institute, Weill Cornell Medical College, New York, New York, USA.
[12]
Agios Pharmaceuticals, Inc, Cambridge, MA, USA.
[13]
Cancer Biology & Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. thompsonc@mskcc.org.
[14]
Human Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. leviner@mskcc.org.;Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA. leviner@mskcc.org.;Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. leviner@mskcc.org.;Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA. leviner@mskcc.org.
[15]
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. steine@mskcc.org.;Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA. steine@mskcc.org.
[16]
医学主题词
等位基因(Alleles);别构部位(Allosteric Site);氨基吡啶类(Aminopyridines);动物(Animals);临床试验, Ⅰ期(主题)(Clinical Trials, Phase I as Topic);临床试验, Ⅱ期(主题)(Clinical Trials, Phase II as Topic);疾病恶化(Disease Progression);抗药性, 肿瘤(Drug Resistance, Neoplasm);酶抑制剂(Enzyme Inhibitors);女(雌)性(Female);谷氨酰胺(Glutamine);戊二酸盐类(Glutarates);HEK293细胞(HEK293 Cells);人类(Humans);异柠檬酸脱氢酶(Isocitrate Dehydrogenase);异亮氨酸(Isoleucine);白血病, 髓样, 急性(Leukemia, Myeloid, Acute);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);模型, 分子(Models, Molecular);突变蛋白质类(Mutant Proteins);突变(Mutation);蛋白质多聚化(Protein Multimerization);三嗪类(Triazines)
DOI
10.1038/s41586-018-0251-7
PMID
29950729
发布时间
2022-08-12
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